调节性 T 细胞消除 cDC1 细胞会危及癌症免疫治疗。
Elimination of cDC1 cells by regulatory T cells jeopardizes cancer immunotherapy.
发表日期：2024
作者：
Peng Liu, Liwei Zhao, Guido Kroemer, Oliver Kepp
来源：
OncoImmunology
摘要：
最近的研究结果表明，新抗原特异性细胞毒性 1 型调节性 T (TR1) CD4 T 细胞可以通过杀死呈递与 MHC II 类结合的肿瘤抗原的 1 型常规树突细胞 (cDC1) 来颠覆癌症免疫疗法。这强调了 cDC1 对于引发抗癌免疫的重要性，但也提出了新的临床挑战。© 2024 作者。经泰勒许可出版
Recent findings revealed that neoantigen-specific cytotoxic type 1 regulatory T (TR1) CD4 T cells can subvert cancer immunotherapy by killing type 1 conventional dendritic cells (cDC1s) that present tumor antigens bound to MHC class II. This underlines the importance of cDC1s for eliciting anticancer immunity but poses a novel clinical challenge.© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.