腹腔穿刺术通常用于治疗患者因腹水引起的不适。腹水压力、腹水量和患者不适之间的关系尚未阐明。我们前瞻性地招募了 2021 年至 2024 年在三级医院接受门诊治疗性腹腔穿刺术的非恶性腹水成年患者。患者在腹腔穿刺术前、穿刺后立即和穿刺后 1 周完成了经过验证的症状调查问卷（ASI-7，最高分 35）。使用开放式压力计测量腹腔穿刺术开始和结束时的腹水压力。进行混合效应线性回归来评估患者特征、压力、容量和症状之间的关系。纳入了 48 名独特患者的 150 次腹腔穿刺术，终末期肝病钠 3.0 模型的平均值为 16.7。平均引流 6.5 L，腹压从平均 13.7 降低至 6.0 cm H2O（10.1 至 4.4 mmHg，p < 0.001），平均症状评分从 22.6 降低至 6.5（p < 0.001）。回归模型发现，当压力高于 6 cm H2O 或 ASI-7 评分为 16 时，症状和腹压呈线性相关（p < 0.01）。较高的患者需要比队列平均身高 (5'8") 每英寸额外引流约 670 毫升，才能达到相同的症状缓解效果。床边测量的压力可用于探索腹腔穿刺术期间腹压的变化。压力、容量和患者水平因素（例如身高）会导致患者症状，但不能完全解释与腹水相关的不适和穿刺术后的缓解。© 2024 作者。 《联合欧洲胃肠病学杂志》由 Wiley periodicals LLC 代表联合欧洲胃肠病学出版。

Paracentesis is commonly used to manage patient discomfort due to ascites. The relationship between ascites pressure, ascites volume, and patient discomfort has not been elucidated.We prospectively enrolled adult patients with non-malignant ascites undergoing outpatient therapeutic paracenteses from 2021 to 2024 at a tertiary care hospital. Patients completed a validated symptom questionnaire (ASI-7, maximum score 35) before, immediately after, and 1 week after paracentesis. An open-ended manometer was used to measure ascites pressure at the beginning and end of paracentesis. Mixed effect linear regression was performed to evaluate the relationships between patient characteristics, pressure, volume, and symptoms.One hundred and fifty paracentesis procedures among 48 unique patients with an average Model for End Stage Liver Disease-Sodium 3.0 of 16.7 were included. An average of 6.5 L was drained, which reduced abdominal pressure from a mean of 13.7 to 6.0 cm H2O (10.1 to 4.4 mmHg, p < 0.001) and mean symptom score from 22.6 to 6.5 (p < 0.001). Regression models identified that symptoms and abdominal pressure linearly correlated above a pressure of 6 cm H2O or ASI-7 score of 16 (p < 0.01). Taller patients required about 670 ml additional drainage per inch above the cohort mean height (5'8″) to achieve the same symptom relief.Pressure measured at the bedside can be used to explore changes in abdominal pressure during paracentesis. Pressure, volume, and patient level factors such as height contribute to patient symptoms but cannot fully explain discomfort associated with ascites and relief after paracentesis.© 2024 The Author(s). United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology.