胰腺癌的进化森林
The Evolutionary Forest of Pancreatic Cancer
DOI 原文链接
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影响因子:33.3
分区:医学1区 Top / 肿瘤学1区
发表日期:2025 Feb 07
作者:
Katelyn M Mullen, Jungeui Hong, Marc A Attiyeh, Akimasa Hayashi, Hitomi Sakamoto, Zachary A Kohutek, Caitlin A McIntyre, Haochen Zhang, Alvin P Makohon-Moore, Amanda Zucker, Laura D Wood, Matthew A Myers, Brian J Arnold, Simone Zaccaria, Joanne F Chou, Marinela Capanu, Nicholas D Socci, Benjamin J Raphael, Christine A Iacobuzio-Donahue
DOI:
10.1158/2159-8290.CD-23-1541
摘要
尽管已描述胰腺癌的基因组，但尚未就其诊断阶段或治疗瓶颈进行系统探索。我们现描述并量化了胰腺导管腺癌（PDAC）在进化指标背景下的基因组特征，并在此过程中发现了一种新的预后生物标志物。
Abstract
Although the pancreatic cancer genome has been described, it has not been explored with respect to stages of diagnosis or treatment bottlenecks. We now describe and quantify the genomic features of PDAC in the context of evolutionary metrics and in doing so have identified a novel prognostic biomarker.