胰腺癌的进化森林
The Evolutionary Forest of Pancreatic Cancer
影响因子:33.30000
分区:医学1区 Top / 肿瘤学1区
发表日期:2025 Feb 07
作者:
Katelyn M Mullen, Jungeui Hong, Marc A Attiyeh, Akimasa Hayashi, Hitomi Sakamoto, Zachary A Kohutek, Caitlin A McIntyre, Haochen Zhang, Alvin P Makohon-Moore, Amanda Zucker, Laura D Wood, Matthew A Myers, Brian J Arnold, Simone Zaccaria, Joanne F Chou, Marinela Capanu, Nicholas D Socci, Benjamin J Raphael, Christine A Iacobuzio-Donahue
摘要
尽管已经描述了胰腺癌基因组，但尚未在诊断或治疗瓶颈方面进行探索。现在，我们在进化指标的背景下描述和量化了PDAC的基因组特征，并在此过程中确定了一种新颖的预后生物标志物。
Abstract
Although the pancreatic cancer genome has been described, it has not been explored with respect to stages of diagnosis or treatment bottlenecks. We now describe and quantify the genomic features of PDAC in the context of evolutionary metrics and in doing so have identified a novel prognostic biomarker.