葛根是一种历史悠久的药食两用植物，在我国广泛使用。葛根素是从葛根中提取的主要成分，具有多种药理特性。近年来，葛根素因其显着的保肝作用而受到越来越多的关注，例如代谢功能障碍相关的脂肪性肝病、酒精性肝病和肝癌等。本文通过炎症因子、氧化应激、脂质代谢、细胞凋亡、自噬等多种机制探讨葛根素对多种肝脏疾病的药理作用。由于其溶解度有限，药代动力学研究表明葛根素的生物利用度较低。然而，将葛根素与新型药物递送系统相结合可以提高其生物利用度。同时，葛根素毒性极低，安全性高，为其进一步发展奠定了坚实的基础。此外，本文还讨论了葛根素的临床试验，突出了其独特的优势。鉴于其优异的药理作用，葛根素有望成为治疗多种肝脏疾病的潜在药物。© 2024。作者。

Pueraria is a time-honored food and medicinal plant, which is widely used in China. Puerarin, the main component extracted from pueraria, has a variety of pharmacological characteristics. In recent years, puerarin has received increasing attention for its significant hepatoprotective effects, such as metabolic dysfunction-associated steatotic liver disease, alcohol-related liver disease, and hepatic carcinoma. This paper explores the pharmacological effects of puerarin on various liver diseases through multiple mechanisms, including inflammation factors, oxidative stress, lipid metabolism, apoptosis, and autophagy. Due to its restricted solubility, pharmacokinetic studies revealed that puerarin has a low bioavailability. However, combining puerarin with novel drug delivery systems can improve its bioavailability. Meanwhile, puerarin has very low toxicity and high safety, providing a solid foundation for its further. In addition, this paper discusses puerarin's clinical trials, highlighting its unique advantages. Given its excellent pharmacological effects, puerarin is expected to be a potential drug for the treatment of various liver diseases.© 2024. The Author(s).