巨自噬/自噬是一种细胞内降解途径，对健康和患病的胰腺都有重要影响。它通过维持细胞器稳态和去除受损的细胞器来保护胰腺的结构和功能。多种胰腺相关疾病，如糖尿病、胰腺炎、胰腺癌等都与自噬密切相关。针对自噬的遗传学研究证实了这一观点。自噬稳态的丧失（缺乏或过度激活）会导致一系列不良反应，例如氧化积累、炎症增加和细胞死亡。越来越多的证据表明，刺激或抑制自噬是多种胰腺疾病的潜在治疗策略。在这篇综述中，我们讨论了自噬在胰腺生理和病理条件下的多重作用，包括其作为保护性或致病性因素的作用。版权所有 © 2024 Zhou、Zhang、Li、Yao、Jiang、Wan、Tang 和 Liu。

Macroautophagy/autophagy is an intracellular degradation pathway that has an important effect on both healthy and diseased pancreases. It protects the structure and function of the pancreas by maintaining organelle homeostasis and removing damaged organelles. A variety of pancreas-related diseases, such as diabetes, pancreatitis, and pancreatic cancer, are closely associated with autophagy. Genetic studies that address autophagy confirm this view. Loss of autophagy homeostasis (lack or overactivation) can lead to a series of adverse reactions, such as oxidative accumulation, increased inflammation, and cell death. There is growing evidence that stimulating or inhibiting autophagy is a potential therapeutic strategy for various pancreatic diseases. In this review, we discuss the multiple roles of autophagy in physiological and pathological conditions of the pancreas, including its role as a protective or pathogenic factor.Copyright © 2024 Zhou, Zhang, Li, Yao, Jiang, Wan, Tang and Liu.