酰基 CoA 结合蛋白 (ACBP)：一种自噬检查点，可用于改善癌症免疫监视。
Acyl CoA binding protein (ACBP): an autophagy checkpoint that can be targeted for improving cancer immunosurveillance.
发表日期：2024
作者：
Léa Montégut, Isabelle Martins, Guido Kroemer
来源：
OncoImmunology
摘要：
DBI 编码的酰基辅酶 A 结合蛋白 (ACBP) 是一种组织激素，可限制多种细胞类型的自噬，因此可作为细胞外自噬检查点。我们最近在《分子癌症》杂志上报道，中和 ACBP 的单克隆抗体可改善乳腺癌和肺癌的免疫监视。此外，ACBP 中和可改善临床前模型中 PD-1 阻断的新辅助化学免疫治疗的结果。© 2024 作者。经泰勒许可出版
Acyl CoA binding protein (ACBP) encoded by DBI is a tissue hormone that limits autophagy in multiple cell types, hence acting as an extracellular autophagy checkpoint. We recently reported in Molecular Cancer that monoclonal antibodies neutralizing ACBP improve immunosurveillance of breast and lung carcinomas. Moreover, ACBP neutralization improves the outcome of neoadjuvant chemoimmunotherapy with PD-1 blockade in preclinical models.© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.