人乳头瘤病毒相关的鼻咽癌：系统评价和荟萃分析
Human papillomavirus-associated nasopharyngeal carcinoma: A systematic review and meta-analysis
影响因子:3.90000
分区:医学2区 / 牙科与口腔外科2区 肿瘤学3区
发表日期:2024 Dec
作者:
Brian Y Zhao, Shun Hirayama, Deborah Goss, Yan Zhao, Daniel L Faden
摘要
已知人乳头瘤病毒（HPV）会影响口咽外的头部和颈部位点，包括鼻咽。与HPV相关的口咽鳞状细胞癌（HPV+OPSCC）不同，与HPV相关的鼻咽癌（HPV+NPC）的表征没有很好地表征，并且在非潜在地区的真实患者的表现不佳。在这里，我们试图在NPC中获得HPV的全球观点，由地理区域进行了分层。在2022年9月21日，系统地搜索了1990年1月1日至2022年9月21日在2022年9月21日发表的文章的可用证据。我们审查了所有研究NPC和HPC患者的文献研究，该文献提供了量子和HPV的研究。该研究遵循了系统评价和荟萃分析（PRISMA）指南的首选报告项目。主要结果和措施包括由地理区域分层的HPV+NPC患病率估计，以及其他临床和人口特征。检索的1567个引用，46项涵盖6314例NPC患者的研究符合统计分析的资格。 HPV+NPC的全球患病率为0.18（95％CI 0.14-0.23）。当按地理区域分层时，北美的患病率最高（0.25，95％CI 0.17-0.36），这是NPC的非特征区域，HPV+OPSCC的患病率也最高。亚洲是一个流行地区，其HPV患病率估计值最低（0.13，95％CI 0.08-0.22）。 HPV 16（44％）和18（33％）是HPV+NPC中的主要基因型，与HPV+OPSCC不同。这项系统的审查和荟萃分析提供了按地理区域分层的HPV+NPC的全球观点，并表明HPV是NPC的重要相位npc。
Abstract
Human papillomavirus (HPV) is known to affect head and neck sites beyond the oropharynx, including the nasopharynx. Unlike HPV-associated oropharyngeal squamous cell carcinoma (HPV+OPSCC), HPV-associated nasopharyngeal carcinoma (HPV+NPC) is not well characterized and the true prevalence in non-endemic regions is poorly described. Here, we sought to obtain a global point prevalence of HPV in NPC, stratified by geographic region.EMBASE, OVID Medline, and Web of Science were systematically searched for available evidence on September 21, 2022 for articles published between January 1, 1990 and September 21, 2022.We reviewed the literature for all studies examining NPC and HPV status in adult patients that provided a quantitative HPV prevalence. The study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Main outcome and measures included HPV+NPC prevalence estimates stratified by geographic region, along with other clinical and demographic features.Of the 1567 citations retrieved, 46 studies encompassing 6314 NPC patients were eligible for statistical analysis. The global prevalence of HPV+NPC was 0.18 (95% CI 0.14-0.23). When stratified by geographic region, prevalence was highest in North America (0.25, 95% CI 0.17-0.36), which is a non-endemic region for NPC and also has highest prevalence for HPV+OPSCC. Asia, an endemic area, had the lowest HPV prevalence estimate (0.13, 95% CI 0.08-0.22). HPV 16 (44%) and 18 (33%) were the predominant genotypes in HPV+NPC, dissimilar to HPV+OPSCC.This systematic review and meta-analysis provides a global point prevalence of HPV+NPC stratified by geographic region and suggests that HPV is a significant etiological factor of NPC in North America.