已知人乳头瘤病毒 (HPV) 会影响口咽部以外的头颈部位，包括鼻咽部。与 HPV 相关口咽鳞状细胞癌 (HPV OPSCC) 不同，HPV 相关鼻咽癌 (HPV NPC) 的特征尚不明确，非流行地区的真实患病率也很少描述。在这里，我们试图获得按地理区域分层的 NPC 中 HPV 的全球点患病率。系统地搜索了 EMBASE、OVID Medline 和 Web of Science，以获取 2022 年 9 月 21 日发表于 1990 年 1 月 1 日至 9 月期间发表的文章的可用证据。 2022 年 2 月 21 日。我们回顾了所有检查成年患者 NPC 和 HPV 状态的研究文献，这些研究提供了定量的 HPV 患病率。该研究遵循系统评价和荟萃分析的首选报告项目 (PRISMA) 指南。主要结果和指标包括按地理区域分层的 HPV NPC 患病率估计，以及其他临床和人口特征。在检索到的 1567 条引用中，涵盖 6314 名 NPC 患者的 46 项研究符合统计分析条件。 HPV NPC 的全球患病率为 0.18（95% CI 0.14-0.23）。按地理区域分层时，北美地区的患病率最高（0.25，95% CI 0.17-0.36），该地区是鼻咽癌非流行地区，也是 HPV OPSCC 患病率最高的地区。亚洲作为流行地区，HPV 患病率估计值最低（0.13，95% CI 0.08-0.22）。 HPV 16 (44%) 和 18 (33%) 是 HPV NPC 的主要基因型，与 HPV OPSCC 不同。这项系统回顾和荟萃分析提供了按地理区域分层的 HPV NPC 的全球点患病率，并表明 HPV 是一种北美鼻咽癌的重要病因。版权所有 © 2024 Elsevier Ltd. 保留所有权利。

Human papillomavirus (HPV) is known to affect head and neck sites beyond the oropharynx, including the nasopharynx. Unlike HPV-associated oropharyngeal squamous cell carcinoma (HPV+OPSCC), HPV-associated nasopharyngeal carcinoma (HPV+NPC) is not well characterized and the true prevalence in non-endemic regions is poorly described. Here, we sought to obtain a global point prevalence of HPV in NPC, stratified by geographic region.EMBASE, OVID Medline, and Web of Science were systematically searched for available evidence on September 21, 2022 for articles published between January 1, 1990 and September 21, 2022.We reviewed the literature for all studies examining NPC and HPV status in adult patients that provided a quantitative HPV prevalence. The study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Main outcome and measures included HPV+NPC prevalence estimates stratified by geographic region, along with other clinical and demographic features.Of the 1567 citations retrieved, 46 studies encompassing 6314 NPC patients were eligible for statistical analysis. The global prevalence of HPV+NPC was 0.18 (95% CI 0.14-0.23). When stratified by geographic region, prevalence was highest in North America (0.25, 95% CI 0.17-0.36), which is a non-endemic region for NPC and also has highest prevalence for HPV+OPSCC. Asia, an endemic area, had the lowest HPV prevalence estimate (0.13, 95% CI 0.08-0.22). HPV 16 (44%) and 18 (33%) were the predominant genotypes in HPV+NPC, dissimilar to HPV+OPSCC.This systematic review and meta-analysis provides a global point prevalence of HPV+NPC stratified by geographic region and suggests that HPV is a significant etiological factor of NPC in North America.Copyright © 2024 Elsevier Ltd. All rights reserved.