不再落后:PD-1 有了新的免疫治疗伙伴。
LAGging behind no more: PD-1 has a new immunotherapy partner.
发表日期:2024 Oct 08
作者:
Andrew J Gunderson
来源:
IMMUNITY
摘要:
PD-1 阻断可部分逆转癌症患者的 T 细胞耗竭,但广泛的反应仍然有限。最近发表在《Cell》上的三项研究阐明了如何通过不同的分子机制废除 LAG-3 和 PD-1 协同作用,进一步推动效应 T 细胞功能。版权所有 © 2024 Elsevier Inc. 保留所有权利。
PD-1 blockade partially reverses T cell exhaustion in cancer patients, but broad responses are still limited. Three studies recently published in Cell illuminate how abrogating LAG-3 and PD-1 synergize to further push effector T cell functionality via distinct molecular mechanisms.Copyright © 2024 Elsevier Inc. All rights reserved.