研究动态
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不再落后:PD-1 有了新的免疫治疗伙伴。

LAGging behind no more: PD-1 has a new immunotherapy partner.

发表日期:2024 Oct 08
作者: Andrew J Gunderson
来源: IMMUNITY

摘要:

PD-1 阻断可部分逆转癌症患者的 T 细胞耗竭,但广泛的反应仍然有限。最近发表在《Cell》上的三项研究阐明了如何通过不同的分子机制废除 LAG-3 和 PD-1 协同作用,进一步推动效应 T 细胞功能。版权所有 © 2024 Elsevier Inc. 保留所有权利。
PD-1 blockade partially reverses T cell exhaustion in cancer patients, but broad responses are still limited. Three studies recently published in Cell illuminate how abrogating LAG-3 and PD-1 synergize to further push effector T cell functionality via distinct molecular mechanisms.Copyright © 2024 Elsevier Inc. All rights reserved.