研究健康和疾病中 T 细胞的系统免疫学方法。
Systems immunology approaches to study T cells in health and disease.
发表日期：2024 Oct 09
作者：
Aaron Yang, Amanda C Poholek
来源：
npj Systems Biology and Applications
摘要：
T 细胞是动态调节的免疫细胞，与感染、癌症和自身免疫等多种疾病有关。测序方法的最新进展为各种疾病环境中 T 细胞的转录和表观遗传调控提供了宝贵的见解。在这篇综述中，我们确定了基于测序的关键方法，这些方法已用于了解疾病中 T 细胞的转录组和表观基因组调控。© 2024。作者。
T cells are dynamically regulated immune cells that are implicated in a variety of diseases ranging from infection, cancer and autoimmunity. Recent advancements in sequencing methods have provided valuable insights in the transcriptional and epigenetic regulation of T cells in various disease settings. In this review, we identify the key sequencing-based methods that have been applied to understand the transcriptomic and epigenomic regulation of T cells in diseases.© 2024. The Author(s).