成纤维细胞生长因子 (FGF) 是细胞信号蛋白，在许多生物过程（细胞发育、修复和代谢）中执行多种生物过程。肿瘤细胞的动态，例如血管生成、转化和增殖，对肿瘤形成具有显着影响，并受到 FGF 的调节。然而，FGF 在卵巢癌 (OC) 中的表达和预后意义仍不清楚。通过一系列计算机分析，我们研究了转录、生存数据、遗传变异、基因-基因相互作用网络、铁死亡相关基因和 DNA我们发现，OC 组织中 FGF18 的表达水平高于正常 OC 组织，而前者的 FGF2/7/10/17/22 表达水平较低，而 FGF1/19 的表达量与OC 患者的肿瘤分期。根据生存分析，OC个体的临床预后与FGF的异常表达相关。 FGF 及其邻近基因的功能主要与细胞对 FGF 刺激的反应有关。 FGF 表达与各种免疫细胞浸润之间呈负相关。本研究阐明了 FGF 与 OC 之间的关系，这可能为 OC 患者预后生物标志物的选择提供新的见解。© 2024。作者。

Fibroblast growth factors (FGFs) are cell signaling proteins that perform multiple biological processes in many biological processes (cell development, repair, and metabolism). The dynamics of tumor cells, such as angiogenesis, transformation, and proliferation, have a significant impact on neoplasia and are modulated by FGFs. FGFs' expression and prognostic significance in ovarian cancer (OC), however, remain unclear.Through a series of in silico analysis, we investigated the transcriptional, survival data, genetic variation, gene-gene interaction network, ferroptosis-related genes, and DNA methylation of FGFs in OC patients.We discovered that while FGF18 expression levels were higher in OC tissues than in normal OC tissues, FGF2/7/10/17/22 expression levels were lower in the former, and that FGF1/19 expression was related to the tumor stage in OC patients. According to the survival analysis, the clinical prognosis of individuals with OC was associated with the aberrant expression of FGFs. The function of FGFs and their neighboring genes was mainly connected to the cellular response to FGF stimulus. There was a negative correlation between FGF expression and various immune cell infiltration.This study clarifies the relationship between FGFs and OC, which might provide new insights into the choice of prognostic biomarkers of OC patients.© 2024. The Author(s).