增殖性疣状白斑（PVL）是一种口腔潜在恶性疾病。仅影响一种组织的形式研究很少，特别是仅影响牙龈的PVL（gPVL），其可能具有更高的恶性转化潜力。本研究的目的是描述 gPVL 及其恶变风险的特征，以更好地提高对这种特定疾病的认识。在 PubMed、Scopus、Web of Science 和 Google Scholar 上进行了系统评价。仅包括报告初步研究、病例报告和病例系列的文章。对癌症患病率、吸烟者比例、年龄和性别比例、gPVL 复发率和死亡率进行荟萃分析。通过阅读标题和摘要，评估了总共 1298 项研究的资格。纳入 14 篇原创文章，共 58 名患者。 gPVL的恶变率为47.75%。死亡率为5.84%。恶变前的平均随访时间为3年。gPVL似乎比其他形式的PVL具有更快的恶变率。寻找解剖病理学或遗传标记可能是预测 gPVL 恶性转化并改善其诊断和治疗的一系列研究。© 2024 作者。约翰·威利出版的《口腔疾病》

Proliferative verrucous leukoplakia (PVL) is an oral potentially malignant disorder. Forms that affect only one tissue are poorly studied, especially the exclusively gingival PVL (gPVL), which may have a more increased malignant transformation potential. The aim of the present study was to characterise the gPVL and its risk of malignant transformation to better raise awareness of this specific disorder.The systematic review was performed on PubMed, Scopus, Web of Science and Google Scholar. Only articles reporting primary studies, case reports and case series were included. The meta-analysis was performed for the cancer prevalence, proportion of smokers, age and sex ratio, recurrences of gPVL and mortality.A total of 1298 studies were assessed for eligibility by reading titles and abstracts. Fourteen original articles were included with a total of 58 patients. The malignant transformation rate of gPVL was 47.75%. The mortality was 5.84%. The mean follow-up duration before malignant transformation was 3 years.gPVL seems to have a faster malignant transformation rate than the other forms of PVL. Finding anatomo-pathological or genetic markers could be a line of research to predict gPVL malignant transformation and improve its diagnosis and treatment.© 2024 The Author(s). Oral Diseases published by John Wiley & Sons Ltd.