铜 (Cu) 是一种重要的微量元素，参与多种生物过程，例如抗氧化防御、线粒体呼吸和生物化合物合成。近年来，出现了一种称为铜凋亡的新理论来解释铜如何诱导程序性细胞死亡。 Cu 靶向三羧酸循环中的硫辛酸酶，随后触发硫辛酸二氢硫辛酰胺 S-乙酰转移酶的寡聚化，导致 Fe-S 簇的丢失并诱导热休克蛋白 70。 妇科恶性肿瘤，包括宫颈癌、卵巢癌和子宫体子宫内膜癌症严重影响女性的生活质量，甚至对她们的生命构成威胁。过量的铜可以通过多种信号通路增强肿瘤生长、增殖、血管生成和转移，从而促进癌症进展。然而，很少有研究调查妇科癌症与铜凋亡的关系。因此，本综述讨论了铜稳态和铜凋亡，同时探讨铜凋亡在预后预测中的潜在用途及其对妇科癌症进展和治疗的影响。此外，我们还探索铜离子载体疗法在治疗妇科恶性肿瘤中的应用。版权所有 © 2024 Huang、Lian 和 Li。

Copper (Cu) is an essential trace element involved in a variety of biological processes, such as antioxidant defense, mitochondrial respiration, and bio-compound synthesis. In recent years, a novel theory called cuproptosis has emerged to explain how Cu induces programmed cell death. Cu targets lipoylated enzymes in the tricarboxylic acid cycle and subsequently triggers the oligomerization of lipoylated dihydrolipoamide S-acetyltransferase, leading to the loss of Fe-S clusters and induction of heat shock protein 70. Gynecological malignancies including cervical cancer, ovarian cancer and uterine corpus endometrial carcinoma significantly impact women's quality of life and even pose a threat to their lives. Excessive Cu can promote cancer progression by enhancing tumor growth, proliferation, angiogenesis and metastasis through multiple signaling pathways. However, there are few studies investigating gynecological cancers in relation to cuproptosis. Therefore, this review discusses Cu homeostasis and cuproptosis while exploring the potential use of cuproptosis for prognosis prediction as well as its implications in the progression and treatment of gynecological cancers. Additionally, we explore the application of Cu ionophore therapy in treating gynecological malignancies.Copyright © 2024 Huang, Lian and Li.