妇科癌症中的肠道和口腔微生物群：相互作用、机制和治疗价值。
Gut and oral microbiota in gynecological cancers: interaction, mechanism, and therapeutic value.
发表日期：2024 Oct 10
作者：
Jian Wu, Jiarui Li, Meina Yan, Ze Xiang
来源：
npj Biofilms and Microbiomes
摘要：
妇科癌症由女性生殖器官发展而来。肠道和口腔中的微生物失调可以通过多种方式相互沟通，导致粘膜破坏、炎症反应、基因组不稳定，最终诱发癌症和病情恶化。在此，我们介绍肠道菌群与口腔菌群相互作用的机制及其在妇科肿瘤发生发展中的变化。此外，还讨论了基于微生物群调节的新治疗方法。© 2024。作者。
Gynecologic cancers develop from the female reproductive organs. Microbial dysbiosis in the gut and oral cavity can communicate with each other through various ways, leading to mucosal destruction, inflammatory response, genomic instability, and ultimately inducing cancer and worsening. Here, we introduce the mechanisms of interactions between gut and oral microbiota and their changes in the development of gynecologic tumors. In addition, new therapeutic approaches based on microbiota modulation are discussed.© 2024. The Author(s).