癌症诱导的远处器官的全身性预处理：为转移细胞建造利基市场
Cancer-induced systemic pre-conditioning of distant organs: building a niche for metastatic cells
影响因子:66.80000
分区:医学1区 Top / 肿瘤学1区
发表日期:2024 Dec
作者:
Nicolas Rabas, Rute M M Ferreira, Stefania Di Blasio, Ilaria Malanchi
摘要
肿瘤细胞与周围的正常细胞相结合，形成异常结构，该结构通过血液和淋巴管甚至神经关联紧密地与宿主有机体整合在一起。使用这些连接，新兴的癌症发送了许多介体，这些介体有效地扰动了整个生物体并诱导遥远组织的变化。这些扰动通过促进更有利的组织环境（NIHE）来偶然地偏爱早期转移性建立，该组织环境支持异物内传播肿瘤细胞的持久性。因为建立早期转移性壁ni代表了转移的关键限制步骤，因此创建更合适的预先调节组织会强烈增强转移性成功。在这篇综述中，我们提供了迄今为止所描述的原发性肿瘤的机制和介体的更新视图，该机制诱导了远处器官的亲构态调节，这有利于早期转移性生态裂形成。考虑到组织稳态的非伴随依赖性扰动也能够触发促异常调节，我们反思了癌症引起的全身调节的性质。我们认为，需要对过程进行转移性进展的过程更全面，以识别预防或治疗机会。
Abstract
From their early genesis, tumour cells integrate with the surrounding normal cells to form an abnormal structure that is tightly integrated with the host organism via blood and lymphatic vessels and even neural associations. Using these connections, emerging cancers send a plethora of mediators that efficiently perturb the entire organism and induce changes in distant tissues. These perturbations serendipitously favour early metastatic establishment by promoting a more favourable tissue environment (niche) that supports the persistence of disseminated tumour cells within a foreign tissue. Because the establishment of early metastatic niches represents a key limiting step for metastasis, the creation of a more suitable pre-conditioned tissue strongly enhances metastatic success. In this Review, we provide an updated view of the mechanisms and mediators of primary tumours described so far that induce a pro-metastatic conditioning of distant organs, which favours early metastatic niche formation. We reflect on the nature of cancer-induced systemic conditioning, considering that non-cancer-dependent perturbations of tissue homeostasis are also able to trigger pro-metastatic conditioning. We argue that a more holistic view of the processes catalysing metastatic progression is needed to identify preventive or therapeutic opportunities.