关于儿科患者使用立体定向放射外科 (SRS) 的数据有限。本系统评价的目的是总结儿童颅脑 SRS 的具体适应症和结果，以代表国际立体定向放射外科学会 (ISRS) 为共识指南提供信息。系统评价使用系统评价和元数据首选报告项目指南-Analyses (PRISMA)，分析了 1989 年至 2021 年间发表的关于 SRS 的英文文章，其中包括至少 5 名儿科患者的结果。 MEDLINE 数据库术语包括肿瘤类型和位置，以及放射外科和年龄特定术语。我们排除了非临床报告、专家意见、评论和评论文章。对髓母细胞瘤、颅咽管瘤、室管膜瘤、神经胶质瘤和动静脉畸形 (AVM) 进行了与局部对照关联的荟萃回归。在确定供审查的 113 篇文章中，68 篇符合纳入标准。这些文章描述了大约 400 名患有良性和恶性脑肿瘤的儿科患者以及 5119 名患有 AVM 的患者接受了颅脑 SRS 治疗。良性肿瘤、恶性肿瘤和动静脉畸形的局部控制率分别为 89%（95% CI，82%-95%）、71%（95% CI，59%-82%）和 65%（95% CI，95% CI）。 ，60%-69%）。未发现局部控制与患者、肿瘤或治疗相关变量存在显着关联。本综述首次总结了 SRS 治疗儿童脑肿瘤和动静脉畸形的具体结果。尽管儿科患者的数据报告有限，但 SRS 似乎提供了可接受的局部控制率。我们提出了 ISRS 共识指南，为儿科患者明智地使用颅脑 SRS 提供信息。© 作者 2024。由牛津大学出版社代表神经肿瘤学会出版。版权所有。如需商业重复使用，请联系 reprints@oup.com 获取转载和转载的翻译权。所有其他权限都可以通过我们网站文章页面上的权限链接通过我们的 RightsLink 服务获得 - 如需了解更多信息，请联系journals.permissions@oup.com。

There are limited data on the use of stereotactic radiosurgery (SRS) for pediatric patients. The aim of this systematic review was to summarize indications and outcomes specific to pediatric cranial SRS to inform consensus guidelines on behalf of the International Stereotactic Radiosurgery Society (ISRS).A systematic review, using the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), analyzed English-language articles on SRS, published between 1989 and 2021, that included outcomes for at least 5 pediatric patients. MEDLINE database terms included tumor types and locations, and radiosurgical and age-specific terms. We excluded nonclinical reports, expert opinions, commentaries, and review articles. Meta-regressions for associations with local control were performed for medulloblastoma, craniopharyngioma, ependymoma, glioma, and arteriovenous malformation (AVM).Of the 113 articles identified for review, 68 met the inclusion criteria. These articles described approximately 400 pediatric patients with benign and malignant brain tumors and 5119 with AVMs who underwent cranial SRS. The rates of local control for benign tumors, malignant tumors, and AVMs were 89% (95% CI, 82%-95%), 71% (95% CI, 59%-82%), and 65% (95% CI, 60%-69%), respectively. No significant associations were identified for local control with patient-, tumor-, or treatment-related variables.This review is the first to summarize outcomes specific to SRS for pediatric brain tumors and AVMs. Although data reporting is limited for pediatric patients, SRS appears to provide acceptable rates of local control. We present ISRS consensus guidelines to inform the judicious use of cranial SRS for pediatric patients.© The Author(s) 2024. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.