内侧蝶骨翼脑膜瘤继发的视力恶化:对患者报告的结果和有助于手术治疗后恢复的因素进行系统评估。
Visual deterioration secondary to medial sphenoid wing meningioma: systematic assessment of patient-reported outcomes and factors contributing to recovery after surgical treatment.
发表日期:2024 Oct 11
作者:
Florian Gessler, Shefqet Hajdari, Anna-Laura Potthoff, Joshua D Bernstock, Ulrich Herrlinger, Marcus Czabanka, Volker Seifert, Hartmut Vatter, Patrick Schuss, Fatma Kilinç, Matthias Schneider
来源:
JOURNAL OF NEUROSURGERY
摘要:
视力(VA)是内侧蝶骨翼脑膜瘤(SWM)手术的重要结果指标。本研究旨在评估 2009 年至 2018 年接受内侧 SWM 手术的患者,肿瘤相关 VA 损伤的恢复情况及其对患者报告结果测量 (PROM) 的影响,作为视力相关生活质量的指标。 ,连续 153 名患有内侧 SWM 的患者在作者的机构接受了手术治疗。使用 Snellen 图在入院时和术后随访检查期间评估肿瘤相关 VA。进行多变量分析以确定术后视力改善的独立预测因素。 PROM 是根据国家眼科研究所 25 项视功能问卷收集的。在患有内侧 SWM 的患者中,153 名患者中的 53 名 (35%) 经历了术前 VA 损伤。整个研究队列的术前视觉症状持续时间中位数为 12 (IQR 3-17) 个月。多变量分析显示,术前视觉症状持续时间≤ 4 个月与术后视力改善独立相关(p = 0.009)。 PROM 评估表明,如果术前视力障碍持续时间≤ 4 个月,则术后总体健康状况 (p = 0.027) 和日常生活活动 (p = 0.031) 类别的定性程度较高。肿瘤相关视力障碍的术前总持续时间与内侧 SWM 手术中术后视力改善程度以及与视力相关的 PROM 显着相关。这些结果可能有助于术前患者咨询,并有助于优化决策和术前对长期视力结果的估计。
Visual acuity (VA) constitutes an important outcome measure in surgery for medial sphenoid wing meningioma (SWM). This study aimed to assess the recovery of tumor-associated impairment of VA and its impact on patient-reported outcome measures (PROMs) as an indication of vision-related quality of life in patients who had undergone surgery for medial SWM.From 2009 to 2018, 153 consecutive patients with medial SWM underwent surgical treatment at the authors' institutions. Tumor-associated VA was evaluated both on admission and during postoperative follow-up examinations, using Snellen charts. Multivariable analysis was performed to identify independent predictors for postoperative improvement of VA. PROMs were collected based on the National Eye Institute 25-Item Visual Function Questionnaire.Of patients with medial SWM, 53 of 153 (35%) experienced preoperative impairment of VA. The median preoperative duration of visual symptoms was 12 (IQR 3-17) months for the entire study cohort. Multivariable analysis revealed a preoperative duration of visual symptoms ≤ 4 months to be independently associated with postoperative improvement of VA (p = 0.009). Evaluation of PROMs indicated a superior postoperative qualitative extent in the overall health (p = 0.027) and activities of daily living (p = 0.031) categories if preoperative duration of visual impairment was ≤ 4 months.The overall preoperative duration of tumor-related visual impairment significantly correlates to the extent of postoperative visual improvement as well as vision-related PROMs in medial SWM surgery. These results might aid in preoperative patient counseling and help optimize decision-making and preoperative estimation of long-term visual outcome.