儿童和成人脑肿瘤的患者预后以及对放疗和化疗的反应存在很大差异。此外，儿童和年轻成人神经胶质瘤中组蛋白和染色质调节蛋白的反复突变的流行表明染色质景观被重新连接以支持致癌程序。这些早期体细胞突变通过改变组蛋白翻译后修饰（PTM）的分布来失调广泛的基因组位点，从而导致染色质可及性和组蛋白密码的变化，从而导致基因转录变化。我们回顾了神经胶质瘤亚型中不同的染色质失衡如何影响细胞命运、增殖、免疫景观和放射抗性等致癌特征。了解表观遗传失调的这些机制对于推进靶向表观遗传治疗具有重大意义。版权所有 © 2024 Elsevier Inc. 保留所有权利。

Brain tumors in children and adults differ greatly in patient outcomes and responses to radiotherapy and chemotherapy. Moreover, the prevalence of recurrent mutations in histones and chromatin regulatory proteins in pediatric and young adult gliomas suggests that the chromatin landscape is rewired to support oncogenic programs. These early somatic mutations dysregulate widespread genomic loci by altering the distribution of histone post-translational modifications (PTMs) and, in consequence, causing changes in chromatin accessibility and in the histone code, leading to gene transcriptional changes. We review how distinct chromatin imbalances in glioma subtypes impact on oncogenic features such as cellular fate, proliferation, immune landscape, and radio resistance. Understanding these mechanisms of epigenetic dysregulation carries substantial implications for advancing targeted epigenetic therapies.Copyright © 2024 Elsevier Inc. All rights reserved.