接受积极癌症治疗或患有转移性癌症的患者患急性胆囊炎的风险增加，通常会去看普通外科医生进行评估和治疗。关于这些患者使用的治疗过程和所取得的临床结果的数据很少。癌症患者急性胆囊炎的最佳治疗需要了解其独特的风险状况和治疗选择。收集了2019年7月1日至2024年2月29日期间10家医院的急诊普外科数据。选择患有急性胆囊炎的患者进行分析。倾向评分匹配用于根据是否存在活动性恶性肿瘤来创建匹配的患者队列。主要结局是 30 天死亡率。次要结局包括并发症、住院时间、再入院和出院处理。调查的过程包括治疗方式、手术时间和手术技术。分析包括 8,673 名患者。平均年龄为 53.2 ± 19 岁，其中 61.4% 为女性，17.8% 为非白人。总共有 3.3% 的患者患有活动性恶性肿瘤。癌症队列中风险调整后的 30 天死亡率较高（比值比：5.85，95% 置信区间：2.38-14.4，P < .001）。癌症患者的感染并发症发生率也较高（比值比：2.55，95% 置信区间：1.54-4.2，P < .001），包括败血症（比值比：2.95，95% 置信区间：1.61-5.39，P < 0.001） .001）和肺炎（比值比：6.67，95% 置信区间：1.75-25.3，P < .005）。癌症患者更有可能接受非手术治疗（比值比：2.85，95% 置信区间：2.11-3.84，P < .001）。在控制其他因素后，患有急性胆囊炎的癌症患者的临床结果更差。此外，随着非手术治疗率的增加，治疗过程也会发生变化。这些结果对该人群的管理具有影响，特别是对同时进行的肿瘤治疗计划的影响。版权所有 © 2024 Elsevier Inc. 保留所有权利。

Patients undergoing active cancer therapy or with metastatic cancer are at increased risk for acute cholecystitis and often present to general surgeons for evaluation and management. There is a paucity of data regarding the treatment processes used in these patients and the clinical outcomes achieved. Optimal management of acute cholecystitis in patients with cancer requires understanding their unique risk profile and options for treatment.Emergency general surgery data were collected at 10 hospitals from July 1, 2019, to February 29, 2024. Patients presenting with acute cholecystitis were selected for analysis. Propensity score matching was used to create matched cohorts of patients by the presence or absence of an active malignancy. The primary outcome was 30-day mortality. Secondary outcomes included complications, length of stay, readmission, and discharge disposition. Processes investigated include treatment modality, time to operation, and surgical technique.The analysis included 8,673 patients. Mean age was 53.2 ± 19 years, 61.4% were female, and 17.8% were non-White. In total, 3.3% of patients had an active malignancy. Risk-adjusted 30-day mortality was higher in the cancer cohort (odds ratio: 5.85, 95% confidence interval: 2.38-14.4, P < .001). Patients with cancer also had higher rates of infectious complications (odds ratio: 2.55, 95% confidence interval: 1.54-4.2, P < .001), including sepsis (odds ratio: 2.95, 95% confidence interval: 1.61-5.39, P < .001) and pneumonia (odds ratio: 6.67, 95% confidence interval: 1.75-25.3, P < .005). Patients with cancer were more likely to receive nonoperative management (odds ratio: 2.85, 95% confidence interval: 2.11-3.84, P < .001).Patients with cancer presenting with acute cholecystitis experience worse clinical outcomes after controlling for other factors. Furthermore, there is variation in the treatment process with increased rates of nonoperative management. These results have implications for the management of this population, particularly in relation to the impact on concurrent oncologic treatment plans.Copyright © 2024 Elsevier Inc. All rights reserved.