由于已经发现癌症病灶的最大代谢活性在癌症进展过程中向病灶边缘移动，因此从放射性示踪剂摄取热点到肿瘤质心（NHOC）和肿瘤周长（NHOP）的归一化距离被建议作为新的F -18 氟脱氧葡萄糖 (FDG) 正电子发射断层扫描/计算机断层扫描 (PET/CT) 参数可以反映癌症的侵袭性。本研究旨在探讨NHOC和NHOP参数是否可以预测乳腺癌患者对新辅助化疗（NAC）的病理反应和无进展生存期（PFS）。本研究回顾性纳入135名接受预处理FDG PET/CT的女性乳腺癌患者并接受 NAC 和随后的手术切除。除了常规 PET/CT 参数外，还根据 PET/CT 图像测量最大 SUV 和峰值 SUV 到肿瘤质心（NHOCmax 和 NHOCpeak）以及到肿瘤周长（NHOPmax 和 NHOPpeak）的归一化距离。 135 名患者，32 例（23.7%）达到病理完全缓解（pCR），34 例（25.2%）在随访期间发生事件。在受试者工作特征（ROC）曲线分析中，NHOCmax 显示预测 pCR 的 ROC 曲线下面积值最高（0.710），其次是 NHOCpeak（0.694）。在多变量逻辑回归分析中，NHOCmax、NHOCpeak 和 NHOPmax 是 pCR 的独立预测因子（p< 0.05）。在多变量生存分析中，NHOCpeak (p = 0.026) 是 PFS 以及代谢肿瘤体积的独立预测因子，NHOCpeak 较高的患者显示 PFS 较差。治疗前 FDG PET/CT 上的 NHOCpeak 可能是预测 NAC 反应的潜在成像参数和乳腺癌患者的生存率。© 2024。作者。

Since it has been found that the maximum metabolic activity of a cancer lesion shifts toward the lesion edge during cancer progression, normalized distances from the hot spot of radiotracer uptake to tumor centroid (NHOC) and tumor perimeter (NHOP) have been suggested as novel F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) parameters that can reflect cancer aggressiveness. This study aimed to investigate whether NHOC and NHOP parameters could predict pathological response to neoadjuvant chemotherapy (NAC) and progression-free survival (PFS) in breast cancer patients.This study retrospectively enrolled 135 female patients with breast cancer who underwent pretreatment FDG PET/CT and received NAC and subsequent surgical resection. From PET/CT images, normalized distances of maximum SUV and peak SUV-to-tumor centroid (NHOCmax and NHOCpeak) and -to-tumor perimeter (NHOPmax and NHOPpeak) were measured, in addition to conventional PET/CT parameters.Of 135 patients, 32 (23.7%) achieved pathological complete response (pCR), and 34 (25.2%) had events during follow-up. In the receiver operating characteristic (ROC) curve analysis, NHOCmax showed the highest area under the ROC curve value (0.710) for predicting pCR, followed by NHOCpeak (0.694). In the multivariate logistic regression analysis, NHOCmax, NHOCpeak, and NHOPmax were independent predictors for pCR (p < 0.05). In the multivariate survival analysis, NHOCpeak (p = 0.026) was an independent predictor for PFS along with metabolic tumor volume, with patients having higher NHOCpeak showing worse PFS.NHOCpeak on pretreatment FDG PET/CT could be a potential imaging parameter for predicting NAC response and survival in patients with breast cancer.© 2024. The Author(s).