必需氨基酸蛋氨酸是多种相互关联的生化途径中硫代谢的重要调节剂。蛋氨酸循环与叶酸循环错综复杂地联系在一起，形成一碳代谢，这是 S-腺苷甲硫氨酸 (SAM) 的重要调节因子。最近的工作强调了蛋氨酸在肿瘤生长和进展中的关键作用，维持多胺合成，并在染色质状态改变（取决于 p53 状态）的 SAM 调节中发挥关键作用，以及促进 NR4A2 mRNA 的 m6A 甲基化，从而调节增殖在食管癌中。因此，塞来昔布（一种特定的 NR4A2 抑制剂）至少在该特定模型中是一种潜在的强大肿瘤生长抑制剂。此外，内源或外源的甲醛可以直接调节 SAM 稳态水平和一碳代谢，与癌症进展相关。这些最新的科学进展让人们对癌症发展所涉及的分子机制及其潜在的治疗调节有了更深入的了解。© 2024。作者，获得 Springer Nature Limited 的独家许可。

The essential amino acid methionine is a crucial regulator of sulfur metabolism in a variety of interconnected biochemical pathways. The methionine cycle is intricately linked to the folate cycle, forming the one-carbon metabolism, a crucial regulator of S-adenosylmethionine, SAM. Recent work highlights methionine's critical role in tumor growth and progression, maintaining polyamine synthesis, and playing a crucial role in the regulation of SAM both in altered chromatin states, depending on p53 status, as well as facilitating m6A methylation of NR4A2 mRNA, hence regulating proliferation in esophageal carcinoma. Accordingly, Celecoxib, a specific NR4A2 inhibitor, is a potentially powerful inhibitor of tumor growth at least in this specific model. Additionally, formaldehyde, from endogenous or exogenous sources, can directly regulate both SAM steady-state-levels and the one-carbon metabolism, with relevant implication in cancer progression. These recent scientific advancements have provided a deeper understanding of the molecular mechanisms involved in cancer development, and its potential therapeutic regulation.© 2024. The Author(s), under exclusive licence to Springer Nature Limited.