此前的研究报告显示，在美国 35-54 岁人群中，女性肺癌发病率高于男性，这扭转了历史上男性发病率较高的局面。我们检查了这种模式是否因州而异。根据北美癌症数据库中 35-54 岁成年人的肺癌发病率（2015-2019 年）数据和行为危险因素监测系统中 20-39 岁成年人的历史吸烟流行率数据（2004-2005 年），发病率在 51 个州中，有 40 个州的女性比率等于或高于男性比率，其中 20 个州存在统计显着性差异（双侧，p<0.05）。相比之下，与男性相比，当前和曾经吸烟的女性患病率在统计上显着较低（分别为 33 个州和 34 个州）或相似。此外，不同性别的历史吸烟率与肺癌发病率之间没有关联。在大多数州，年轻女性的肺癌发病率高于年轻男性，并且无法用吸烟率的差异来解释。© 2024 UICC。

Previous studies reported higher lung cancer incidence in women than men among persons aged 35-54 years in the United States, a reversal of historically higher rates in men. We examined whether this pattern varies by state. Based on lung cancer incidence (2015-2019) data among adults aged 35-54 years from Cancer in North America database and historical cigarette smoking prevalence data (2004-2005) among adults 20-39 years from the Behavioral Risk Factor Surveillance System, incidence rates in women were equal to or higher than rates in their male counterparts in 40 of 51 states, with statistically significant differences in 20 states (two-sided, p < .05). In contrast, current and ever smoking prevalence in women compared to men was statistically significantly lower (33 and 34 states, respectively) or similar. Furthermore, there was no association between differences in historical smoking prevalence and lung cancer incidence by sex. Lung cancer incidence rate is higher in young women than young men in most states and is unexplained by differences in smoking prevalence.© 2024 UICC.