对于儿童血液恶性肿瘤（CHM）可能的环境危险因素仍然知之甚少。先前的研究表明，紫外线辐射 (UVR) 暴露与儿童患急性淋巴细胞白血病 (ALL) 的风险降低相关。我们调查了瑞士的太阳 UVR 暴露与 CHM 风险之间的关联，瑞士是一个地形和天气条件差异很大的国家。我们纳入了 1990 年至 2016 年间瑞士国家队列中所有 0-15 岁的常住儿童，并通过与瑞士儿童癌症登记处的概率记录联系来识别癌症病例。我们使用空间分辨率为 1.5 的正午（上午 11 点至下午 3 点）紫外线指数 (UVI) 气候模型估算了 2004 年至 2018 年期间儿童之家的总体年平均紫外线水平和 7 月份的平均紫外线水平。 -2公里。使用风险集抽样，我们获得了与出生年份相匹配的嵌套病例对照数据集，并拟合了条件逻辑回归模型（实际上相当于使用比例风险模型分析完整队列数据），并根据性别、社区社会经济地位、城市化程度进行调整，空气污染和背景电离辐射。我们的分析包括 1446 例中药病例。 7 月份 UVI 每单位增加的估计调整后风险比 (HR) 对于白血病为 0.76 (95% CI 0.59-0.98)，对于 ALL 为 0.74 (0.55-0.98)。年度暴露结果相似，但置信区间更宽，并且包含一个。我们没有发现任何证据表明与淋巴瘤整体（HR 1.14，每年暴露的 95% CI 0.59-2.19）或诊断亚组相关。我们的研究进一步支持暴露于环境太阳 UVR 与儿童 ALL 之间的负相关关系。© 2024 作者。约翰·威利出版的《国际癌症杂志》

Still little is known about possible environmental risk factors of childhood hematological malignancies (CHM). Previous studies suggest that ultraviolet radiation (UVR) exposure is associated with a lower risk of acute lymphoblastic leukemia (ALL) in children. We investigated the association between solar UVR exposure and risk of CHM in Switzerland, a country with greatly varying topography and weather conditions. We included all resident children aged 0-15 years from the Swiss National Cohort during 1990-2016 and identified incident cancer cases through probabilistic record linkage with the Swiss Childhood Cancer Registry. We estimated the overall annual mean UV level and the mean level for the month of July during 2004-2018 at children's homes using a climatological model of the midday (11 am-3 pm) UV-index (UVI) with a spatial resolution of 1.5-2 km. Using risk-set sampling, we obtained a nested case-control data set matched by birth year and fitted conditional logistic regression models (virtually equivalent to analyzing full cohort data using proportional hazards models) adjusting for sex, neighborhood socio-economic position, urbanization, air pollution, and background ionizing radiation. Our analyses included 1446 cases of CHM. Estimated adjusted hazard ratios (HR) per unit increase in UVI in July were 0.76 (95% CI 0.59-0.98) for leukemia and 0.74 (0.55-0.98) for ALL. Results for annual exposure were similar but confidence intervals were wider and included one. We found no evidence for an association for lymphoma overall (HR 1.14, 95% CI 0.59-2.19 for annual exposure) or diagnostic subgroups. Our study provides further support for an inverse association between exposure to ambient solar UVR and childhood ALL.© 2024 The Author(s). International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.