数字乳房断层合成 (DBT) 与全视野数字乳房 X 线摄影 (FFDM) 使女性暴露在更高的辐射剂量下。合成 2D 乳房 X 光检查 (S2D) 是由 DBT 构建的二维图像。我们的目的是评估单独使用或与 DBT 结合使用时的 S2D 性能，与单独使用 FFDM 或与 DBT 相比较。如果他们招募筛选参与者并报告 S2D 表现，则研究被纳入。如果研究包括有症状的患者、成像用于诊断目的或参与者有乳腺癌病史，则研究被排除。在可能的情况下，对癌症检出率 (CDR) 和特异性进行了荟萃分析。在各个研究中计算了成像方式性能的差异，并通过荟萃分析汇总了这些差异。在确定的 3241 条记录中，有 17 项研究纳入了审查，13 项研究纳入了荟萃分析。报告 DBT 加 S2D 与 FFDM 的各项研究以及报告 DBT 加 S2D 与 DBT 加 FFDM 的各项研究之间每千人 CDR 的估计综合差异分别为 2.03 (95% CI 0.81-3.25) 和 - 0.15 (95% CI -1.17)至 0.86）。在比较 DBT 加 S2D 和 FFDM 的研究中，估计特异性百分比差异为 1.13（95%CI -0.06 至 2.31）。在比较 DBT 加 S2D 和 DBT 加 FFDM 的研究中，特异性的估计差异为 1.08 (95%CI 0.59-1.56)。 DBT 加 S2D 的准确性与 FFDM 加 DPT 相当，并且比单独的 FFDM 改进了癌症检测。在乳腺癌筛查中将 S2D 与 DBT 相结合是安全的，并且可以保持性能。© 2024 作者。约翰·威利出版的《国际癌症杂志》

Digital breast tomosynthesis (DBT) with full-field digital mammography (FFDM) exposes women to a higher radiation dose. A synthetic 2D mammogram (S2D) is a two-dimensional image constructed from DBT. We aim to evaluate the S2D performance when used alone or combined with DBT compared to FFDM alone or with DBT. Studies were included if they recruited screening participants and reported on S2D performance. Studies were excluded if they included symptomatic patients, imaging was for diagnostic purposes, or if participants had a breast cancer history. Meta-analyses for cancer detection rates (CDR) and Specificities were conducted where available. Differences in the performance of imaging modalities were calculated within individual studies, and these were pooled by meta-analysis. Out of 3241 records identified, 17 studies were included in the review and 13 in the meta-analysis. The estimated combined difference in CDRs per thousand among individual studies that reported on DBT plus S2D vs. FFDM and those reporting on DBT plus S2D versus DBT plus FFDM was 2.03 (95% CI 0.81-3.25) and - 0.15 (95% CI -1.17 to 0.86), respectively. The estimated difference in percent specificities was 1.13 (95% CI -0.06 to 2.31) in studies comparing DBT plus S2D and FFDM. In studies comparing DBT plus S2D and DBT plus FFDM, the estimated difference in specificities was 1.08 (95% CI 0.59-1.56). DBT plus S2D showed comparable accuracy to FFDM plus DPT and improved cancer detection to FFDM alone. Integrating S2D with DBT in breast cancer screening is safe and preserves performance.© 2024 The Author(s). International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.