规定的运动计划对转移性乳腺癌患者的影响：系统评价
The effects of a prescribed exercise programme in people with metastatic breast cancer: a systematic review
影响因子:3.00000
分区:医学3区 / 康复医学3区
发表日期:2024 Dec
作者:
Joyce M C V O' Riordan, Ruth McCullagh, Paul J Murphy, Grainne Sheill, Frances Horgan, Helen P French
摘要
为了合成有关乳腺癌转移性锻炼计划（PWMBC）的效果的可用证据。搜索到2024年1月。包括培训PWMBC进行运动干预。主要结果是生活质量（QOL）。次要结果包括身体表现，肌肉健康，与癌症相关的疲劳（CRF）和体育活动（PA）。由于纳入的研究数量较少，无法进行半分析。我们计算了效果大小（ES），其中有95％的置信区间（95％CI）的单个研究，调整了较小的样本量。科恩（Cohen）的小（0.2至0.5），中度（0.5至0.8）和大（> 0.8）的标准描述了效果的大小。使用Cochrane（ROB）1个工具评估偏差（ROB）的风险。包括三个RCT（n = 149 PWMBC）。结果表明，主要结果QOL中没有明显的组间影响。在CRF中观察到有利于规定运动的影响（ES 1.3，95％CI 0.06至2.35）和PA（ES 0.83，95％CI 0.14至1.42）在两项单独的研究中，因为95％CI的下限，因为处方中的情况下没有相当大的措施。 PWMBC的性能，肌肉健康，CRF和PA。需要进一步的高质量试验来研究PWMBC.prospero CRD42022304528中运动干预措施的有效性。论文的贡献。
Abstract
To synthesise available evidence on the effects of a prescribed exercise programme in People with Metastatic Breast Cancer (PwMBC).Medline, Embase, CINAHL, Web of Science and Scopus were searched up to January 2024.Randomised controlled trials (RCTs) recruiting PwMBC to an exercise intervention were included. The primary outcome was Quality of Life (QOL). Secondary outcomes included physical performance, muscle health, cancer-related fatigue (CRF) and physical activity (PA).Meta-analysis was not possible due to the low number of included studies. We calculated the effect size (ES), with 95% confidence intervals (95% CIs) of individual studies, adjusting for small sample size. Cohen's criteria for small (0.2 to 0.5), moderate (0.5 to 0.8) and large (>0.8) describe the size of the effect. Risk of bias (ROB) was assessed using the Cochrane (ROB) version 1 tool.Three RCTs (n = 149 PwMBC) were included. Results showed no significant between-group effects in the primary outcome, QOL. Whilst effects in favour of prescribed exercise were observed in CRF (ES 1.3, 95% CI 0.06 to 2.35) and PA (ES 0.83, 95% CI 0.14 to 1.42) in two separate studies, as the lower bound of the 95% CI did not reach Cohen's threshold, there is considerable uncertainty regarding the treatment effect.There is currently insufficient evidence to support the use of prescribed exercise to improve QOL, physical performance, muscle health, CRF and PA in PwMBC. Further high-quality trials are required to investigate the effectiveness of exercise interventions in PwMBC.PROSPERO CRD42022304528. CONTRIBUTION OF THE PAPER.