旨在综合证明指定运动计划对转移性乳腺癌 (PwMBC) 患者的影响的现有证据。检索 Medline、Embase、CINAHL、Web of Science 和 Scopus 截至 2024 年 1 月。随机对照试验 (RCT) 将 PwMBC 纳入一项研究运动干预也包括在内。主要结局是生活质量（QOL）。次要结局包括身体表现、肌肉健康、癌症相关疲劳 (CRF) 和体力活动 (PA)。由于纳入的研究数量较少，无法进行荟萃分析。我们计算了个体研究的效应大小 (ES)，其置信区间 (95% CI) 为 95%，并针对小样本量进行了调整。科恩的小（0.2 至 0.5）、中（0.5 至 0.8）和大（>0.8）标准描述了效应的大小。使用 Cochrane (ROB) 第 1 版工具评估偏倚风险 (ROB)。纳入了三项随机对照试验 (n=149 PwMBC)。结果显示主要结局 QOL 没有显着的组间效应。在两项独立的研究中，在 CRF（ES 1.3，95% CI 0.06 至 2.35）和 PA（ES 0.83，95% CI 0.14 至 1.42）中观察到有利于规定运动的效果，正如 95% CI 的下限一样未达到科恩阈值，治疗效果存在相当大的不确定性。目前没有足够的证据支持使用规定的运动来改善 PwMBC 的 QOL、身体表现、肌肉健康、CRF 和 PA。需要进一步的高质量试验来调查 PwMBC.PROSPERO CRD42022304528 中运动干预的有效性。论文贡献。版权所有 © 2024 作者。由爱思唯尔有限公司出版。保留所有权利。

To synthesise available evidence on the effects of a prescribed exercise programme in People with Metastatic Breast Cancer (PwMBC).Medline, Embase, CINAHL, Web of Science and Scopus were searched up to January 2024.Randomised controlled trials (RCTs) recruiting PwMBC to an exercise intervention were included. The primary outcome was Quality of Life (QOL). Secondary outcomes included physical performance, muscle health, cancer-related fatigue (CRF) and physical activity (PA).Meta-analysis was not possible due to the low number of included studies. We calculated the effect size (ES), with 95% confidence intervals (95% CIs) of individual studies, adjusting for small sample size. Cohen's criteria for small (0.2 to 0.5), moderate (0.5 to 0.8) and large (>0.8) describe the size of the effect. Risk of bias (ROB) was assessed using the Cochrane (ROB) version 1 tool.Three RCTs (n = 149 PwMBC) were included. Results showed no significant between-group effects in the primary outcome, QOL. Whilst effects in favour of prescribed exercise were observed in CRF (ES 1.3, 95% CI 0.06 to 2.35) and PA (ES 0.83, 95% CI 0.14 to 1.42) in two separate studies, as the lower bound of the 95% CI did not reach Cohen's threshold, there is considerable uncertainty regarding the treatment effect.There is currently insufficient evidence to support the use of prescribed exercise to improve QOL, physical performance, muscle health, CRF and PA in PwMBC. Further high-quality trials are required to investigate the effectiveness of exercise interventions in PwMBC.PROSPERO CRD42022304528. CONTRIBUTION OF THE PAPER.Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.