前列腺癌微环境：免疫细胞、血管系统、间质细胞及微生物群的多维调控
Prostate cancer microenvironment: multidimensional regulation of immune cells, vascular system, stromal cells, and microbiota
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影响因子:33.9
分区:医学1区 Top / 生化与分子生物学1区 肿瘤学1区
发表日期:2024 Oct 12
作者:
Lin Chen, Yu-Xin Xu, Yuan-Shuo Wang, Ying-Ying Ren, Xue-Man Dong, Pu Wu, Tian Xie, Qi Zhang, Jian-Liang Zhou
DOI:
10.1186/s12943-024-02137-1
摘要
前列腺癌（PCa）是全球男性中最常见的恶性肿瘤之一。近年来，研究重点逐渐转向PCa微环境，该微环境在肿瘤进展和治疗耐药中起着关键作用。本综述旨在全面介绍PCa微环境的关键组成部分，包括免疫细胞、血管系统、间质细胞和微生物群，并探讨它们在诊断和治疗中的潜在意义。文献检索采用PubMed和Web of Science等在线数据库，关键词包括“前列腺癌”、“肿瘤微环境”、“免疫细胞”、“血管系统”、“间质细胞”和“微生物群”。选择了与PCa微环境相关的研究，特别关注免疫细胞、血管系统、间质细胞和微生物群在PCa的发生、发展及治疗中的作用。筛选标准优先考虑近五年内发表的同行评议文章，以总结和分析最新的研究进展及其临床相关性。PCa微环境高度复杂且动态变化，免疫细胞可能促发免疫抑制状态，间质细胞促进肿瘤生长，微生物群潜在影响雄激素代谢。血管系统支持血管生成，促进肿瘤扩展。深入理解这些组成部分，有助于揭示驱动PCa进展的机制，并为靶向微环境的创新治疗策略提供思路。认识到PCa微环境的重要性，有助于推动诊断技术的提升和精准治疗的发展。本综述强调靶向微环境以改善患者预后，强调其在PCa研究及治疗创新中的关键作用。
Abstract
Prostate cancer (PCa) is one of the most prevalent malignancies in males worldwide. Increasing research attention has focused on the PCa microenvironment, which plays a crucial role in tumor progression and therapy resistance. This review aims to provide a comprehensive overview of the key components of the PCa microenvironment, including immune cells, vascular systems, stromal cells, and microbiota, and explore their implications for diagnosis and treatment.Keywords such as "prostate cancer", "tumor microenvironment", "immune cells", "vascular system", "stromal cells", and "microbiota" were used for literature retrieval through online databases including PubMed and Web of Science. Studies related to the PCa microenvironment were selected, with a particular focus on those discussing the roles of immune cells, vascular systems, stromal cells, and microbiota in the development, progression, and treatment of PCa. The selection criteria prioritized peer-reviewed articles published in the last five years, aiming to summarize and analyze the latest research advancements and clinical relevance regarding the PCa microenvironment.The PCa microenvironment is highly complex and dynamic, with immune cells contributing to immunosuppressive conditions, stromal cells promoting tumor growth, and microbiota potentially affecting androgen metabolism. Vascular systems support angiogenesis, which fosters tumor expansion. Understanding these components offers insight into the mechanisms driving PCa progression and opens avenues for novel therapeutic strategies targeting the tumor microenvironment.A deeper understanding of the PCa microenvironment is crucial for advancing diagnostic techniques and developing precision therapies. This review highlights the potential of targeting the microenvironment to improve patient outcomes, emphasizing its significance in the broader context of PCa research and treatment innovation.