前列腺癌微环境：免疫细胞，血管系统，基质细胞和微生物群的多维调节
Prostate cancer microenvironment: multidimensional regulation of immune cells, vascular system, stromal cells, and microbiota
影响因子:33.90000
分区:医学1区 Top / 生化与分子生物学1区 肿瘤学1区
发表日期:2024 Oct 12
作者:
Lin Chen, Yu-Xin Xu, Yuan-Shuo Wang, Ying-Ying Ren, Xue-Man Dong, Pu Wu, Tian Xie, Qi Zhang, Jian-Liang Zhou
摘要
前列腺癌（PCA）是全球男性最普遍的恶性肿瘤之一。越来越多的研究注意力集中在PCA微环境上，该环境在肿瘤进展和耐药性中起着至关重要的作用。 This review aims to provide a comprehensive overview of the key components of the PCa microenvironment, including immune cells, vascular systems, stromal cells, and microbiota, and explore their implications for diagnosis and treatment.Keywords such as "prostate cancer", "tumor microenvironment", "immune cells", "vascular system", "stromal cells", and "microbiota" were used for literature通过在线数据库中检索，包括PubMed和Web of Science。选择了与PCA微环境有关的研究，特别关注那些讨论免疫细胞，血管系统，基质细胞和微生物群在PCA发育，进展和治疗中的作用的研究。在过去五年中发表的同行评审文章的优先级优先级，旨在总结和分析有关PCA微环境的最新研究进步和临床相关性。PCA微环境高度复杂且动态性，具有免疫细胞，有助于免疫抑制性细胞增长，并促进tomob and tumob，并促进了tomob and tamor and Microbiog，并促进了Microbiog，并促进了Microbiog，并促进了Microbiot，并促进了Microbs，并有助于。血管系统支持血管生成，从而促进肿瘤扩张。了解这些成分可深入了解推动PCA进展的机制，并为针对肿瘤微环境的新型治疗策略开辟了途径。对PCA微环境的更深入了解对于推进诊断技术和开发精确治疗至关重要。这篇评论强调了针对微环境改善患者结果的潜力，强调了其在PCA研究和治疗创新更广泛的背景下的重要性。
Abstract
Prostate cancer (PCa) is one of the most prevalent malignancies in males worldwide. Increasing research attention has focused on the PCa microenvironment, which plays a crucial role in tumor progression and therapy resistance. This review aims to provide a comprehensive overview of the key components of the PCa microenvironment, including immune cells, vascular systems, stromal cells, and microbiota, and explore their implications for diagnosis and treatment.Keywords such as "prostate cancer", "tumor microenvironment", "immune cells", "vascular system", "stromal cells", and "microbiota" were used for literature retrieval through online databases including PubMed and Web of Science. Studies related to the PCa microenvironment were selected, with a particular focus on those discussing the roles of immune cells, vascular systems, stromal cells, and microbiota in the development, progression, and treatment of PCa. The selection criteria prioritized peer-reviewed articles published in the last five years, aiming to summarize and analyze the latest research advancements and clinical relevance regarding the PCa microenvironment.The PCa microenvironment is highly complex and dynamic, with immune cells contributing to immunosuppressive conditions, stromal cells promoting tumor growth, and microbiota potentially affecting androgen metabolism. Vascular systems support angiogenesis, which fosters tumor expansion. Understanding these components offers insight into the mechanisms driving PCa progression and opens avenues for novel therapeutic strategies targeting the tumor microenvironment.A deeper understanding of the PCa microenvironment is crucial for advancing diagnostic techniques and developing precision therapies. This review highlights the potential of targeting the microenvironment to improve patient outcomes, emphasizing its significance in the broader context of PCa research and treatment innovation.