在之前的随机对照试验中，使用低剂量计算机断层扫描 (LDCT) 进行肺癌筛查已被证明可以降低肺癌死亡率和总体死亡率。尽管取得了这些成果，在法国进行有组织的筛查仍然是一个挑战。本研究评估了法国行政区域现实生活中肺癌筛查的可行性和有效性。DEP KP80 是一项单臂前瞻性研究。参与者年龄在 55 岁至 74 岁之间，吸烟者或吸烟年数≥30 包年的前吸烟者均被招募。每年安排一次 LDCT 扫描并进行三轮。受试者由全科医生或肺科医生选择，他们检查纳入标准并规定进行 CT 扫描。2016 年 3 月至 2020 年 2 月期间，共招募了 1254 名参与者。总体而言，945 名（75.4％）参与者接受了基线 LDCT（T0），376 名（42.8％）完成了第一轮（T1），270 名（31％）完成了第二轮（T2）。诊断出 42 例肺癌，其中 30 例（71.4%）为 I 期或 II 期癌症，34 例（80.9%）接受了手术治疗。在这项研究中，阳性筛查的总体阳性预测值为48%（95% CI 37-59），阴性预测值为100%（95% CI 100-100）。这项研究证明了肺癌的可行性和有效性在现实生活中进行筛查，大多数肺癌在早期诊断并通过手术切除。我们的结果还强调了参与每一轮的重要性，强调了优化组织是一个主要目标的事实。Agence Régionale de Santé de Picardie、La Ligue contre le cancer、le Conseil Départemental de la Somme 和 AstraZeneca。版权所有 © 2024 The作者。由 Elsevier B.V. 出版。保留所有权利。

In prior randomised controlled trials, lung cancer screening using low-dose computed tomography (LDCT) has been shown to reduce lung cancer mortality and overall mortality. Despite these results, organised screening in France remains a challenge. This study assessed the feasibility and efficacy of lung cancer screening within a real-life context in a French administrative territory.DEP KP80 was a single-arm prospective study. Participants aged between 55 and 74 years, smokers or former smokers of ≥30 pack-years, were recruited. An annual LDCT scan was scheduled and three rounds were performed. Subjects were selected by general practitioners or pulmonologists, who checked the inclusion criteria and prescribed the CT scan.Between March 2016 and February 2020, 1254 participants were enrolled. Overall, 945 (75.4%) participants underwent baseline LDCT (T0), 376 (42.8%) completed the first round (T1) and 270 (31%) the second (T2) one. Forty-two lung cancers were diagnosed, 30 cancers (71.4%) were stage I or II and 34 cancers (80.9%) were treated surgically. In this study, the overall positive predictive value for a positive screening was 48% (95% CI 37-59) and the negative predictive value 100% (95% CI 100-100).This study demonstrated the feasibility and efficacy of lung cancer screening in a real-life context with most lung cancers diagnosed at an early stage and surgically removed. Our results also highlighted the importance of participation in each round, underlining the fact that optimising organisation is a major goal.Agence Régionale de Santé de Picardie, La Ligue contre le cancer, le Conseil Départemental de la Somme, and AstraZeneca.Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.