癌症中钙激活的钾通道（KCA3.1）：新兴角色和治疗潜力
Intermediate conductance calcium-activated potassium channel (KCa3.1) in cancer: Emerging roles and therapeutic potentials
影响因子:5.60000
分区:医学2区 / 药学2区
发表日期:2024 Dec
作者:
Nhung Thi Hong Van, Joo Hyun Nam
摘要
KCA3.1通道（也称为KCNN4，IK1或SK4通道）是一种中间导电钙激活的钾通道，可调节膜电位并维持钙稳态。最近，KCA3.1渠道因其在各种类型的癌症中的各种作用而引起了人们的关注。在癌细胞中，KCA3.1通道调节关键过程，包括细胞增殖，细胞周期，迁移，入侵，肿瘤微环境和耐药性。此外，癌症中异常的KCA3.1表达用于区分肿瘤和正常组织，对癌症阶段进行分类并预测患者的生存结果。这篇综述全面研究了对KCA3.1通道对肿瘤形成，转移及其机制的贡献的当前理解。我们评估了KCA3.1作为癌症诊断和预后的生物标志物的潜力。最后，我们讨论了在癌症治疗中应用KCA3.1调节剂的进步和挑战，并提出了克服这些障碍的方法。总而言之，这篇评论凸显了该离子通道是癌症的有效治疗靶标和预后生物标志物的重要性。
Abstract
The KCa3.1 channel (also known as the KCNN4, IK1, or SK4 channel) is an intermediate-conductance calcium-activated potassium channel that regulates the membrane potential and maintains calcium homeostasis. Recently, KCa3.1 channels have attracted increasing attention because of their diverse roles in various types of cancers. In cancer cells, KCa3.1 channels regulate key processes, including cell proliferation, cell cycle, migration, invasion, tumor microenvironments, and therapy resistance. In addition, abnormal KCa3.1 expression in cancers is utilized to distinguish between tumor and normal tissues, classify cancer stages, and predict patient survival outcomes. This review comprehensively examines the current understanding of the contribution of KCa3.1 channels to tumor formation, metastasis, and its mechanisms. We evaluated the potential of KCa3.1 as a biomarker for cancer diagnosis and prognosis. Finally, we discuss the advances and challenges of applying KCa3.1 modulators in cancer treatment and propose approaches to overcome these obstacles. In summary, this review highlights the importance of this ion channel as a potent therapeutic target and prognostic biomarker of cancer.