癌症中的中等导电钙激活钾通道（KCa3.1）：新兴作用及治疗潜力
Intermediate conductance calcium-activated potassium channel (KCa3.1) in cancer: Emerging roles and therapeutic potentials
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影响因子:5.6
分区:医学2区 / 药学2区
发表日期:2024 Dec
作者:
Nhung Thi Hong Van, Joo Hyun Nam
DOI:
10.1016/j.bcp.2024.116573
摘要
KCa3.1通道（亦称KCNN4、IK1或SK4通道）是一种中等导电的钙激活钾通道，调节细胞膜电位并维持钙稳态。近年来，KCa3.1通道因其在多种癌症中的多样作用而受到越来越多关注。在癌细胞中，KCa3.1调控关键过程，包括细胞增殖、细胞周期、迁移、侵袭、肿瘤微环境和治疗抵抗。此外，癌症中异常表达的KCa3.1被用作区分肿瘤与正常组织、分类癌症阶段以及预测患者生存结局的标志物。本文综述了KCa3.1通道在肿瘤发生、转移中的作用及其机制的研究进展。我们评估了KCa3.1作为癌症诊断和预后生物标志物的潜力。最后，探讨了KCa3.1调节剂在癌症治疗中的应用前景与挑战，并提出了克服这些障碍的策略。综上所述，该离子通道作为潜在的治疗靶点和预后标志物，具有重要的临床意义。
Abstract
The KCa3.1 channel (also known as the KCNN4, IK1, or SK4 channel) is an intermediate-conductance calcium-activated potassium channel that regulates the membrane potential and maintains calcium homeostasis. Recently, KCa3.1 channels have attracted increasing attention because of their diverse roles in various types of cancers. In cancer cells, KCa3.1 channels regulate key processes, including cell proliferation, cell cycle, migration, invasion, tumor microenvironments, and therapy resistance. In addition, abnormal KCa3.1 expression in cancers is utilized to distinguish between tumor and normal tissues, classify cancer stages, and predict patient survival outcomes. This review comprehensively examines the current understanding of the contribution of KCa3.1 channels to tumor formation, metastasis, and its mechanisms. We evaluated the potential of KCa3.1 as a biomarker for cancer diagnosis and prognosis. Finally, we discuss the advances and challenges of applying KCa3.1 modulators in cancer treatment and propose approaches to overcome these obstacles. In summary, this review highlights the importance of this ion channel as a potent therapeutic target and prognostic biomarker of cancer.