皮肤药物发现 3D 临床前模型的进展和前景。
Advances in, and prospects of, 3D preclinical models for skin drug discovery.
发表日期：2024 Oct 11
作者：
Mohammad Imran, Peter Moyle, Danielle Kamato, Yousuf Mohammed
来源：
DRUG DISCOVERY TODAY
摘要：
皮肤在调节体内平衡和保护身体免受内源性和外源性微环境影响方面发挥着重要作用。尽管用于药物发现的 3D 模型已得到广泛研究，但对更先进的 3D 皮肤模型以加强皮肤研究的需求不断增长。这些先进皮肤模型的使用在化妆品、皮肤病治疗和新疗法的毒性测试等领域具有广阔的前景。最近的进展包括芯片皮肤、球体、重建皮肤、类器官和计算方法的开发，包括定量结构-活性关系（QSAR）和定量结构-性质关系（QSPR）研究。这些创新正在弥合传统 2D 和先进 3D 模型之间的差距，推动从研究到临床应用的进展。在这篇综述中，我们重点介绍了用于皮肤相关应用的具有先进药物发现的体外和计算皮肤模型。版权所有 © 2024 作者。由爱思唯尔有限公司出版。保留所有权利。
The skin has an important role in regulating homeostasis and protecting the body from endogenous and exogenous microenvironments. Although 3D models for drug discovery have been extensively studied, there is a growing demand for more advanced 3D skin models to enhance skin research. The use of these advanced skin models holds promise across domains such as cosmetics, skin disease treatments, and toxicity testing of new therapeutics. Recent advances include the development of skin-on-a-chip, spheroids, reconstructed skin, organoids, and computational approaches, including quantitative structure-activity relationship (QSAR) and quantitative structure-property relationship (QSPR) research. These innovations are bridging the gap between traditional 2D and advanced 3D models, moving progress from research to clinical applications. In this review, we highlight in vitro and computational skin models with advanced drug discovery for skin-related applications.Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.