半定量PET特征和3B级卵泡淋巴瘤中疗法终止宠物的价值
The value of semiquantitative PET features and end-of-therapy PET in grade 3B follicular lymphoma
影响因子:3.80000
分区:医学2区 / 血液学2区
发表日期:2024 Dec
作者:
Allison Barraclough, Sze Ting Lee, Diego Villa, Greg Hapgood, Don Wilson, Geoffrey Chong, Eliza A Hawkes
摘要
3B级卵泡淋巴瘤（G3BFL）是一种罕见的淋巴瘤，据说坐落在低级FL和弥漫性大B细胞淋巴瘤（DLBCL）之间的连续体上。定量正电子发射断层扫描（PET）指标的预后影响，例如总代谢性肿瘤体积（TMTV），总病变糖酵解（TLG）和最大标准摄取值（SUVMAX），但在FL和DLBCL中已广泛分析G3BFL数据，但缺乏G3BFL数据。在这里，我们描述了46例用R-Chop（类似）化学疗法均匀治疗的G3BFL病例中的PET结果和放射线特征。使用MIM软件的中央半自动化PET TMTV，TLG和SUVMAX分析与临床结果相关，并将其与低级FL和DLBCL的发布结果进行了比较。在G3BFL中，治疗结束完全的代谢反应与提高无进展的生存率（PFS; P = 0.002）和总生存期（OS; P = 0.04）有关。 G3BFL中位数TLG（1455）和SUVMAX（16.50）位于低级FL（TLG：1112，SUVMAX：11.3）和DLBCL（TLG：3004，SUVMAX，SUVMAX：24.35）之间。 TMTV（> 350 cm3）与存活率之间未见（PFS：P = 0.24； OS：P = 0.40）。高Suvmax（> 19.2）和TLG（> 2760）都赋予下PFS，但不提供OS（PFS：Suvmax P = 0.004； TLG P = 0.05）。这些数据支持在基线上的PET放射线学和G3BFL的治疗反应的常规融合。
Abstract
Grade 3B follicular lymphoma (G3BFL) is a rare lymphoma thought to sit on a continuum between low-grade FL and diffuse large B-cell lymphoma (DLBCL). The prognostic impact of quantitative positron emission tomography (PET) metrics such as total metabolic tumour volume (TMTV), total lesion glycolysis (TLG), and maximum standard uptake value (SUVmax) have been extensively analysed in FL and DLBCL, but G3BFL data are lacking. Here, we describe PET outcomes and radiomic characteristics in 46 G3BFL cases uniformly treated with R-CHOP (like) chemotherapy. Central semi-automated PET TMTV, TLG, and SUVmax analyses, using MIM software, were correlated with clinical outcomes and compared with published results in low-grade FL and DLBCL. In G3BFL, the end-of-treatment complete metabolic response was associated with improved progression-free survival (PFS; p = 0.002) and overall survival (OS; p = 0.04). G3BFL median TLG (1455) and SUVmax (16.50) sit between published values for low-grade FL (TLG: 1112, SUVmax: 11.3) and DLBCL (TLG: 3004, SUVmax: 24.35). No association between TMTV (>350 cm3) and survival was seen (PFS: p = 0.24; OS: p = 0.40). High SUVmax (>19.2) and TLG (>2760) both conferred inferior PFS but not OS (PFS: SUVmax p = 0.004; TLG p = 0.05). These data support the routine incorporation of PET radiomics at baseline and treatment response for G3BFL.