研究动态
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干扰素依赖性和独立信号通路的作用:对癌症的影响。

Role of interferon dependent and independent signaling pathways: Implications in cancer.

发表日期:2024
作者: Sheila Spada, Anirban Ganguly
来源: International Review of Cell and Molecular Biology

摘要:

干扰素 (IFN) 是一类具有有效抗病毒和免疫调节特性的细胞因子,可通过多种信号通路调节免疫系统。在癌症中,干扰素对于影响抗肿瘤免疫质量以及对癌症治疗(包括免疫治疗)的反应的肿瘤内在和外在机制至关重要。然而,需要更深入、更好地了解 IFN 在癌细胞中引发免疫信号传导的机制。在这篇综述中,我们重点关注癌症中的 IFN 依赖性轴和独立轴,将其作为新免疫治疗方法的靶向中心,以提高治疗效果并规避癌症耐药性,从而改善临床结果。版权所有 © 2024。由 Elsevier Inc. 出版。
Interferons (IFNs) are a class of cytokines with potent antiviral and immunomodulatory properties that regulate the immune system through multiple signaling pathways. In cancer, IFNs are vital to both tumor-intrinsic and extrinsic mechanisms that affect the quality of antitumor immunity as well as response to cancer treatments, including immunotherapy. However, there is a need for a deeper and better understanding of the mechanisms by which IFNs elicit immune signalling in cancerous cells. In this review, we focus on the IFN- dependent and independent axes in cancer as targetable hubs for new immunotherapeutic approaches to boost the treatment efficacy and to circumvent cancer resistance leading to improved clinical outcomes.Copyright © 2024. Published by Elsevier Inc.