转录因子 p53（由 TP53 编码）在人类发育和疾病中发挥着多种作用。虽然 p53 信号传导以其在肿瘤抑制中的作用而闻名，但它还通过触发细胞命运决定来响应各种压力，从而影响哺乳动物的发育。经过 4 多年的研究，最近发现了一种响应有丝分裂延迟而触发 p53 激活的新途径。 USP28 和 53BP1 蛋白被称为有丝分裂监视或有丝分裂秒表途径，它们响应有丝分裂进展延迟而激活 p53，以控制细胞命运并促进基因组稳定性。在这篇小综述中，我讨论了它的识别、在神经发育障碍和癌症中的潜在作用，并探讨了有关其功能、调节和作为抗有丝分裂疗法生物标志物的潜在用途的突出问题。版权所有 © 2024 Stracker。

The transcription factor p53 (encoded by TP53) plays diverse roles in human development and disease. While best known for its role in tumor suppression, p53 signaling also influences mammalian development by triggering cell fate decisions in response to a wide variety of stresses. After over 4 decades of study, a new pathway that triggers p53 activation in response to mitotic delays was recently identified. Termed the mitotic surveillance or mitotic stopwatch pathway, the USP28 and 53BP1 proteins activate p53 in response to delayed mitotic progression to control cell fate and promote genomic stability. In this Minireview, I discuss its identification, potential roles in neurodevelopmental disorders and cancer, as well as explore outstanding questions about its function, regulation and potential use as a biomarker for anti-mitotic therapies.Copyright © 2024 Stracker.