光热疗法是一种有前途的肿瘤治疗方法，可以选择性地消除癌细胞，同时确保正常细胞的存活。它将光能转化为热能，温和、有针对性、无辐射。然而，治疗中缺乏准确、无创的体温测量方法，阻碍了治疗效果。因此，迫切需要一种实时、准确的无创测温方法。本文介绍了一种基于热应变光声 (PA) 温度测量的尝试。首先对该方法进行了建模，并开发了基于圆形阵列的光声光热系统。使用印度墨水作为肿瘤模拟物的实验表明，这项工作中的温度监测精度达到了低至 0.3 °C。此外，还可以实现实时温度成像，为光热治疗提供精确的二维温度图。还在人类手指和裸鼠上进行了实验，验证了所提出的方法在实际实施中的前景。© 2024 作者。

Photothermal therapy is a promising tumor treatment approach that selectively eliminates cancer cells while assuring the survival of normal cells. It transforms light energy into thermal energy, making it gentle, targeted, and devoid of radiation. However, the efficacy of treatment is hampered by the absence of accurate and noninvasive temperature measurement method in the therapy. Therefore, there is a pressing demand for a noninvasive temperature measurement method that is real-time and accurate. This article presents one such attempt based on thermal strain photoacoustic (PA) temperature measurement. The method was first modelled, and a circular array-based photoacoustic photothermal system was developed. Experiments with Indian ink as tumor simulants suggest that the temperature monitoring in this work achieves a precision of down to 0.3 °C. Furthermore, it is possible to accomplish real-time temperature imaging, providing accurate two-dimensional temperature mapping for photothermal therapy. Experiments were also conducted on human fingers and nude mice, validating promising potentials of the proposed method for practical implementations.© 2024 The Authors.