癌症治疗相关的间质性肺疾病。
Cancer therapy-related interstitial lung disease.
发表日期：2024 Oct 11
作者：
Chengzhi Zhou, Haiyi Deng, Yilin Yang, Fei Wang, Xinqing Lin, Ming Liu, Xiaohong Xie, Tao Luan, Nanshan Zhong
来源：
CHINESE MEDICAL JOURNAL
摘要：
随着癌症治疗的使用不断增加，与这些治疗相关的肺损伤的发生率持续上升。对与癌症治疗相关的肺毒性的认识变得越来越重要，间质性肺疾病（ILD）是癌症治疗的常见死因。癌症治疗相关 ILD (CT-ILD) 可由多种治疗引起，包括化疗、靶向治疗、免疫检查点抑制剂、抗体药物偶联物和放射治疗。 CT-ILD可能进展迅速，甚至危及生命；因此，及时诊断、及时治疗对于有效管理至关重要。本综述旨在提供有关 CT-ILD 相关风险因素的有价值的信息；阐明其基本机制；讨论其临床特征、影像学和组织学表现；并强调其诊断的临床相关观点。此外，本综述还概述了用于 CT-ILD 管理的分级、分型和分期治疗策略。版权所有 © 2024 中华医学会，由 Wolters Kluwer, Inc. 根据 CC-BY-NC-ND 制作执照。
With the increasing utilization of cancer therapy, the incidence of lung injury associated with these treatments continues to rise. The recognition of pulmonary toxicity related to cancer therapy has become increasingly critical, for which interstitial lung disease (ILD) is a common cause of mortality. Cancer therapy-related ILD (CT-ILD) can result from a variety of treatments including chemotherapy, targeted therapy, immune checkpoint inhibitors, antibody-drug conjugates, and radiotherapy. CT-ILD may progress rapidly and even be life-threatening; therefore, prompt diagnosis and timely treatment are crucial for effective management. This review aims to provide valuable information on the risk factors associated with CT-ILD; elucidate its underlying mechanisms; discuss its clinical features, imaging, and histological manifestations; and emphasize the clinical-related views of its diagnosis. In addition, this review provides an overview of grading, typing, and staging treatment strategies used for the management of CT-ILD.Copyright © 2024 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.