结直肠癌 (CRC) 会导致生命损失和重大经济负担，而结直肠癌筛查可以减轻这些负担。我们评估了挽救生命和就业的潜力，以评估台湾结直肠癌筛查计划的有效性。通过台湾癌症登记处之间的相互联系，根据国家死亡登记处、台湾结直肠癌筛查数据库和国民健康保险索赔数据，我们纳入了 2004 年至 2017 年诊断的年龄 50-74 岁的结直肠腺癌患者，并随访至 2018 年。预期寿命 (LE)、终身雇佣与年龄、性别和日历年匹配的队列进行比较，计算了持续时间 (LED)、LE 损失和 LED 损失。假设屏幕检测到的 CRC 与非屏幕检测到的 CRC 在特定阶段内没有差异，并按不同阶段分布对它们进行加权，我们比较了 LE 总丢失和 LED 丢失。该队列纳入了 77,169 名结直肠腺癌患者，其中包括 31,728 名女性（平均 [SD] 年龄，62.5 [7.1] 岁）和 45,441 名男性（平均 [SD] 年龄，62.8 [6.8] 岁）。女性的平均 LE 丧失和 LED 丧失分别为 6.0（95% 置信区间 [CI] 5.7-6.3）和 1.0（95% CI 0.8-1.1）年，而男性为 5.1 年分别为 (95% CI 4.9-5.4) 和 1.1 (95% CI 1.0-1.2) 年。在该队列中，有 53,678 例病例有筛查信息。平均而言，每例女性的筛查可能会延长 2.9 (95% CI 2.6-3.2) 年的预期寿命加上 0.5 (95% CI 0.4-0.6) 年的就业年限，以及 2.7 (95% CI 2.5-3.0) 年的就业年限加上 0.6 (95% CI 2.5-3.0) 年的就业年限。男性的 95% CI 分别为 0.5-0.7) 年。台湾 CRC 筛查计划与挽救生命和延长就业期限相关。未来的研究有必要在考虑到挽救就业损失并可能调整交付时间偏差后评估在年轻时开始筛查的成本效益。© 2024 作者。 《联合欧洲胃肠病学杂志》由 Wiley periodicals LLC 代表联合欧洲胃肠病学出版。

Colorectal cancer (CRC) leads to life loss and a significant economic burden, which could be reduced by CRC screening.We assessed the potential savings of lives and employment to evaluate the effectiveness of the Taiwan CRC Screening Programme.Through interlinkages among Taiwan Cancer Registry, National Mortality Registry, Taiwan CRC Screening Database, and National Health Insurance claim data, we enroled patients with colorectal adenocarcinoma, aged 50-74 years and diagnosed during 2004-2017, and followed them up to 2018. Life expectancy (LE), lifetime employment duration (LED), loss-of-LE and loss-of-LED were calculated, compared with age-, sex- and calendar year-matched cohorts. Assuming no difference within a specific stage for screen-detected versus non-screen detected CRC and weighting them by different stage distributions, we compared the total loss-of-LE and loss-of-LED.The cohort enroled 77,169 patients with colorectal adenocarcinoma, which included 31,728 women (mean [SD] age, 62.5 [7.1] years) and 45,441 men (mean [SD] age, 62.8 [6.8] years). The mean loss-of-LE and loss-of-LED in women were 6.0 (95% confidence interval [CI] 5.7-6.3) and 1.0 (95% CI 0.8-1.1) year(s), whereas those in men were 5.1 (95% CI 4.9-5.4) and 1.1 (95% CI 1.0-1.2) years, respectively. Among the cohort, 53,678 cases had the screening information. On average, screening potentially saved 2.9 (95% CI 2.6-3.2) years of life expectancy plus 0.5 (95% CI 0.4-0.6) years of employment per case in women and 2.7 (95% CI 2.5-3.0) years plus 0.6 (95% CI 0.5-0.7) years in men, respectively.The Taiwan CRC Screening Programme is associated with the savings of lives and employment duration. Future studies are warranted to evaluate the cost-effectiveness of beginning screening at a younger age after accounting for saving employment loss and possibly adjusting lead time bias.© 2024 The Author(s). United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology.