成熟脾 B 细胞淋巴瘤是一组神秘的淋巴肿瘤，由于各实体之间诊断特征的重叠以及用于评估的脾组织的可用性不断降低，长期以来给执业病理学家带来了巨大的困难。虽然一些实体具有高度特征性和特定的临床病理学特征（例如毛细胞白血病），但其他实体更难以识别（例如脾弥漫性红髓淋巴瘤）。与此同时，分类系统也在不断发展，导致这些实体之间的边界发生多重变化，甚至导致一些实体本身的存在。此外，过去十年对脾 B 细胞淋巴瘤的公正多组学研究（全基因组/转录组测序、甲基化组）使我们对这些肿瘤的基础生物学有了重要的了解。我们整合多组学数据，对脾 B 细胞淋巴瘤的诊断和分类的历史、当前和未来状态提出临床病理学视角，并强调该领域的重点领域，以便继续努力通过准确的诊断来改善患者的预后.© 2024 作者。组织病理学由约翰·威利出版

The mature splenic B-cell lymphomas are an enigmatic group of lymphoid neoplasms that have long caused significant difficulty for the practicing pathologist due to overlapping diagnostic features among entities and the decreasing availability of splenic tissue for assessment. While some entities have highly characteristic and specific clinicopathological features (e.g. hairy cell leukaemia), others are substantially more difficult to recognise (e.g. splenic diffuse red pulp lymphoma). At the same time, classification systems have been evolving, resulting in multiple changes to the boundaries among these entities and even the existence of some entities in their own right. Moreover, unbiased multi-omic interrogation (whole genome/transcriptome sequencing, methylome) of the splenic B-cell lymphomas over the past decade has given us significant insights into the underling biology of these neoplasms. We present a clinicopathological perspective on the historical, current and future state of the diagnosis and classification of splenic B-cell lymphomas integrating multi-omic data and highlighting areas of focus for the field in order to continue to strive to improve patient outcomes through accurate diagnosis.© 2024 The Author(s). Histopathology published by John Wiley & Sons Ltd.