肝结核和肺结核中病理特征和免疫微环境的表征
Characterization of pathological features and immune microenvironment in hepatic tuberculosis and pulmonary tuberculosis
影响因子:4.80000
分区:医学2区 / 免疫学2区 微生物学2区
发表日期:2024
作者:
Qiang Niu, Runrui Wu, Ke Pan, Xinlan Ge, Wen Chen, Rong Liu
摘要
肝结核病（HTB）是罕见的肺外结核病，在临床上与肝脏恶性肿瘤相似，因此很难正确诊断。病理是结核病诊断的金标准。但是，关于HTB的病理特征的报道很少。总共考虑了32例HTB病例，并分析了病理特征和耐药性的差异，并将其与肺结核（PTB）进行了比较。增强的CT扫描显示动脉，静脉和延迟相期间的环形延迟增强。大多数HTB病例是单个病变，右叶发病率最高，平均病变体积小于PTB。病理变化中颗粒瘤的频率，HTB组病变区域的整体份额以及FOXP3+细胞的数量明显高于PTB组。但是，两组的其他病理特征和免疫细胞数量之间没有观察到统计学上的显着差异。进一步分析了病变周围正常组织的免疫微环境。研究结果表明，HTB组中巨噬细胞和FOXP3+细胞的数量明显高于PTB组。 HTB和PTB组之间的耐药性差异没有显着差异。总之，HTB和PTB之间的病理特征和免疫微环境的表征存在实质性差异。与PTB相比，HTB的肉芽肿频率和随后的病变区域的总体份额明显更高。
Abstract
Hepatic tuberculosis (HTB) is rare extrapulmonary tuberculosis that is clinically similar to liver malignancy, making it difficult for correct diagnoses. Pathology is the gold standard for tuberculosis diagnosis. However, there are few reports on the pathological features of HTB. A total of 32 HTB cases were considered and the differences in pathological features and drug resistance were analyzed and compared with those for pulmonary tuberculosis (PTB). Enhanced CT scans showed ring-shaped delayed enhancement during the arterial, venous, and delayed phases. Most HTB cases were single lesions, with the highest incidence in the right lobe, and the average lesion volume was smaller than that of PTB. The frequency of granuloma in pathological changes, the overall share of the lesion area in the HTB group, and the number of foxp3+ cells were significantly higher than in the PTB group. However, no statistically significant differences were observed between the two groups' other pathological features and immune cell numbers. The immune microenvironment of the normal tissues surrounding the lesion was further analyzed. The findings showed that the number of macrophages and foxp3+ cells in the HTB group was significantly higher than in the PTB group. No significant difference in drug resistance was detected between the HTB and PTB groups. In conclusion, there are substantial differences in the characterization of pathological feature and immune microenvironment between HTB and PTB. The frequency of granuloma and subsequent overall share of the lesion area was significantly higher in HTB compared to PTB.