环境污染是一个严重的公共卫生问题，因为它对人类健康和生物多样性都有不利影响。在西方国家，许多人体生物监测（HBM）研究是为了评估人群接触污染物的情况。相比之下，非洲的 HBM 研究数量非常少。 测量金沙萨成年人口中砷、铅、4,4'-二氯二苯基二氯乙烯 (4,4'-DDE) 和多氯联苯 (PCB) 的污染情况，并确定在目前的工作中，我们测量了从刚果首都金沙萨招募的 151 名志愿者采集的样本中尿液中的砷和血液中的铅以及血清中的 4,4'-DDE 和多氯联苯 (PCB) 的污染情况。刚果民主共和国 (DRC)。大多数样品中均检测到 PCB 180、-153 和 -138，中位浓度分别为 0.04、0.05 和 0.04 ng/ml。 4,4'-DDE 的中位浓度为 0.83 ng/ml，12.7% 的人口污染程度高于 3.675 ng/ml，这与显着较高的癌症风险相关。砷浓度也很高（中位值：尿液中的砷浓度为 48.1 微克/升）。最后，铅暴露也是一个问题：中位血液浓度为 54.9 μg/L，高于世界卫生组织和美国疾病预防控制中心提出的启动临床干预的阈值（分别为 50 μg/L 和 35 μg/L），而铅的浓度为 12.6 μg/L。 % 的人口铅含量超过 100 µg/L，这与多种健康结果相关。我们的结果强调了在非洲开展进一步 HBM 研究的必要性，并应鼓励刚果民主共和国当局实施法律法规，以减少污染和人口暴露。版权所有 © 2024。由 Elsevier GmbH 出版。

Environmental pollution is a serious public health problem because of its adverse effects on both human health and biodiversity. In Western countries, many human biomonitoring (HBM) studies are conducted to assess population exposure to pollutants. In contrast, the number of HBM studies in Africa is very low.To measure contamination by arsenic, lead, 4,4'-dichlorodiphenyldichloroethylene (4,4'-DDE) and polychlorobiphenyls (PCBs) in the adult population of Kinshasa and to identify the susceptible population.In the present work, we measured the contamination by arsenic in urine and lead in blood and by 4,4'-DDE and polychlorobiphenyls (PCBs) in serum in samples collected from 151 volunteers recruited in Kinshasa, the capital of the Democratic Republic of Congo (DRC).The PCBs 180, -153 and -138 were detected in most samples with median concentrations of 0.04, 0.05 and 0.04 ng/ml, respectively. The median concentration of 4,4'-DDE was 0.83 ng/ml and 12.7% of our population showed contamination above the threshold of 3.675 ng/ml, which is associated with a significantly higher risk of cancer. Arsenic concentrations were also high (median: 48.1 μg/L in urine). Finally, exposure to lead is problematic: the median blood concentration was 54.9 μg/L, which is above the thresholds proposed by the WHO and the US CDC (50 μg/L and 35 μg/L respectively) to initiate clinical intervention, and 12.6% of the population had a lead level above 100 μg/L, which is associated with several health outcomes.Our results highlight the need for further HBM studies in Africa and should encourage the authorities of the DRC to implement laws and regulations to reduce pollution and population exposure.Copyright © 2024. Published by Elsevier GmbH.