采用组合柱色谱法从南海软珊瑚 Sinulariaecta 中分离出 11 种新的大环 casbane 型二萜，即 sinueracasbanones E-O (1-11)。通过广泛的光谱数据分析、改进的Mosher方法、X射线衍射分析和量子力学计算方法阐明了新化合物的结构。在生物测定中，化合物 2、5、10 和 11 通过抑制脂多糖 (LPS) 诱导的肿瘤坏死因子 (TNF)-α 蛋白释放而表现出有趣的抗炎活性，半数抑制浓度 (IC50) 值为 15.6、7.1分别为 、13.7 和 6.6 µM。版权所有 © 2024 Elsevier B.V。保留所有权利。

Eleven new macrocyclic casbane-type diterpenes, namely sinueracasbanones E-O (1-11), have been isolated from the South China Sea soft coral Sinularia erecta using combined column chromatography. The structures of new compounds were elucidated by extensive spectroscopic data analysis, the modified Mosher's method, X-ray diffraction analysis and quantum mechanical calculation methods. In bioassay, compounds 2, 5, 10 and 11 displayed interesting anti-inflammatory activities by the inhibition of lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α protein release with half maximal inhibitory concentration (IC50) values of 15.6, 7.1, 13.7 and 6.6 µM, respectively.Copyright © 2024 Elsevier B.V. All rights reserved.