在2018-2022的大学医院（2018-2022）中血液学恶性肿瘤患者的侵入性真菌感染：一项观察性研究
Invasive fungal infections in patients with haematological malignancies at the University Hospital of Reunion Island (2018-2022): An observational study
影响因子:2.30000
分区:医学3区 / 兽医学2区 传染病学3区 真菌学3区
发表日期:2024 Oct 04
作者:
Camille Estagnasié, Catherine Mohr, Laure Kamus, Patricia Zunic, Emmanuel Chirpaz, Marie-Pierre Moiton, Marie Lagrange-Xelot
摘要
对于血液学患者来说，侵入性真菌感染是严重的并发症。但是，在聚会岛上没有关于这一主题的研究。这项研究的目的是估计聚会岛大学医院血液学恶性肿瘤患者侵入性真菌感染的发生率。我们进行了描述性和雄心勃勃的研究。我们包括任何患有出血性恶性肿瘤的患者，该患者以推定，可能，可能或证明的侵入性真菌感染，根据2018年1月至2022年12月的欧洲研究和治疗组织的2019年欧洲研究和治疗组织的标准定义。在76例患者中诊断出了89例侵入性真菌感染。侵入性真菌感染的5年发病率为每100人年1.7（95％置信区间（CI）1.3-2）。侵入性曲霉菌病是最常见的感染（35/89，39％），其次是浸润性念珠菌病（33/89，37％），粘膜菌病（7/89，8％）和肺炎细胞病（7/89，89％）。大多数感染发生在急性髓样白血病（32/89，36％）和淋巴瘤（26/89，29％）的患者中。粘膜菌病（71％）的六个月死亡率高于曲霉病（34％）和浸润性念珠菌病（33％）。血液学患者中真菌感染的发病率和分布与欧洲同类群相似，尽管有更多的粘膜菌病，较少的肺炎囊肿和念珠菌念珠菌的大部分念珠菌。
Abstract
Invasive fungal infections are a serious complication for haematology patients. However, there is no study on this subject in Reunion Island. The aim of this study was to estimate the incidence of invasive fungal infections in patients with haematological malignancies at the University Hospital of Reunion Island. We conducted a descriptive and ambispective study. We included any patient with haematological malignancy presenting with a putative, possible, probable, or proven invasive fungal infection, defined as per the criteria of the European Organisation for Research and Treatment of Cancer/Mycoses Study Group 2019, from January 2018 to December 2022. Data were collected from medical records and identified by ICD-10 coding and laboratory data. Eighty-nine invasive fungal infections were diagnosed in 76 patients. The 5-year incidence rate of invasive fungal infections was 1.7 per 100 person-years (95% Confidence Interval (CI) 1.3-2). Invasive aspergillosis was the most common infection (35/89, 39%), followed by invasive candidiasis (33/89, 37%), mucormycosis (7/89, 8%), and pneumocystosis (7/89, 8%). Most infections occurred in patients with acute myeloid leukaemia (32/89, 36%) and lymphoma (26/89, 29%). Six-month mortality was higher for mucormycosis (71%) than for aspergillosis (34%) and invasive candidiasis (33%). The incidence and distribution of fungal infections in haematology patients were similar to European cohorts, albeit with more mucormycosis, less pneumocystis, and a high proportion of Candida parapsilosis in candidemia.