具有在人类呼吸道中复制能力的人畜共患病毒对公共健康构成威胁。类器官是代表特定器官或组织的高度代表性的多细胞模型，可以帮助我们了解人畜共患病毒的发病机制、致病性、传播性和储存库循环动力学。类器官研究可以促进抗病毒疗法的快速选择，识别潜在的储存宿主物种和中间宿主，并为选择合适的实验动物模型提供信息。我们回顾了使用来自多个器官的人类和动物类器官模型来研究引起呼吸道疾病的新兴人畜共患病毒的威胁。由 Elsevier B.V. 出版

Zoonotic viruses with the ability to replicate in the human respiratory tract pose a threat to public health. Organoids, which are highly representative, multicellular models representing specific organs or tissues, can aid in our understanding of the pathogenesis, pathogenicity, transmissibility, and reservoir circulation dynamics of zoonotic viruses. Organoid studies can facilitate the rapid selection of antiviral therapies identification of potential reservoir species and intermediate hosts, and inform the selection of suitable laboratory animal models. We review the use of human- and animal-derived organoid models from multiple organs to investigate the threat of emerging zoonotic viruses that cause respiratory disease.Published by Elsevier B.V.