通过类器官促进人畜共患呼吸道病毒研究的进展
Advancing zoonotic respiratory virus research through the use of organoids
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影响因子:5.1
分区:医学2区 / 病毒学2区
发表日期:2024
作者:
Meaghan Flagg, Emmie de Wit
DOI:
10.1016/j.coviro.2024.101435
摘要
具有在人体呼吸道复制能力的动物源病毒对公共健康构成威胁。类器官是一种高度代表性、多细胞模型，代表特定器官或组织，有助于理解动物源病毒的发病机制、毒性、传播能力及宿主循环动态。类器官研究可以促进快速筛选抗病毒疗法、识别潜在的宿主物种和中间宿主，并为选择合适的实验动物模型提供依据。本文回顾了多器官来源的人类和动物类器官模型在研究新兴动物源病毒引发的呼吸系统疾病中的应用。由Elsevier B.V.发表。
Abstract
Zoonotic viruses with the ability to replicate in the human respiratory tract pose a threat to public health. Organoids, which are highly representative, multicellular models representing specific organs or tissues, can aid in our understanding of the pathogenesis, pathogenicity, transmissibility, and reservoir circulation dynamics of zoonotic viruses. Organoid studies can facilitate the rapid selection of antiviral therapies identification of potential reservoir species and intermediate hosts, and inform the selection of suitable laboratory animal models. We review the use of human- and animal-derived organoid models from multiple organs to investigate the threat of emerging zoonotic viruses that cause respiratory disease.Published by Elsevier B.V.