通过使用器官来推进人畜共患呼吸道病毒研究
Advancing zoonotic respiratory virus research through the use of organoids
影响因子:5.10000
分区:医学2区 / 病毒学2区
发表日期:2024
作者:
Meaghan Flagg, Emmie de Wit
摘要
在人类呼吸道中复制的动物病毒对公共卫生构成威胁。器官是代表特定器官或组织的高度代表性的多细胞模型，可以帮助我们理解人畜共患病毒的发病机理，致病性，可传播性和储层循环动力学。器官研究可以促进潜在储层物种和中间宿主的抗病毒疗法的快速选择，并告知选择合适的实验室动物模型的选择。我们审查了来自多个器官的人类和动物衍生的器官模型的使用来研究引起呼吸系统疾病的新兴人畜共患病毒的威胁。
Abstract
Zoonotic viruses with the ability to replicate in the human respiratory tract pose a threat to public health. Organoids, which are highly representative, multicellular models representing specific organs or tissues, can aid in our understanding of the pathogenesis, pathogenicity, transmissibility, and reservoir circulation dynamics of zoonotic viruses. Organoid studies can facilitate the rapid selection of antiviral therapies identification of potential reservoir species and intermediate hosts, and inform the selection of suitable laboratory animal models. We review the use of human- and animal-derived organoid models from multiple organs to investigate the threat of emerging zoonotic viruses that cause respiratory disease.Published by Elsevier B.V.