肠道微生物群对免疫细胞相互作用及癌症治疗的影响
Influence of the gut microbiota on immune cell interactions and cancer treatment
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影响因子:7.5
分区:医学2区 Top / 医学：研究与实验2区
发表日期:2024 Oct 15
作者:
Chunxiao Liu, Lingfeng Fu, Yuxin Wang, Weijun Yang
DOI:
10.1186/s12967-024-05709-3
摘要
肿瘤微环境（TME）代表肿瘤学研究中的一个新前沿。过去十年中，积累的证据强调了肿瘤微环境的重要性，包括肿瘤细胞、基质细胞、免疫细胞及各种分泌因子，这些因素共同影响肿瘤的生长、侵袭以及对治疗药物的反应。免疫细胞在TME中的作用已被广泛认可为肿瘤发生与治疗的关键。尽管一些观点认为TME中的免疫细胞促进肿瘤进展并赋予抗药性，仍存在相反的结论。这些结论的正负性似乎取决于具体的研究背景，尚未达成统一共识。近年来关于肠道微生物群与肿瘤关系的研究不断增加，逐渐增进了理解。大多数研究表明，肠道微生物的特定组成或分泌因子在调控TME中的免疫细胞方面起着多样作用，从而影响癌症的预后和治疗效果。深入理解这些因素，有望为肿瘤微环境和癌症治疗提供新的见解。本研究旨在综述肠道微生物群与TME中免疫细胞相互作用的相关研究，为未来癌症治疗的指导提供深度探索。
Abstract
The tumour microenvironment represents a novel frontier in oncological research. Over the past decade, accumulating evidence has underscored the importance of the tumour microenvironment (TME), including tumour cells, stromal cells, immune cells, and various secreted factors, which collectively influence tumour growth, invasion, and responses to therapeutic agents. Immune cells within the TME are now widely acknowledged to play pivotal roles in tumour development and treatment. While some perspectives have posited that immune cells within the TME facilitate tumour progression and confer resistance to therapeutic interventions, contrasting conclusions also exist. Affirmative and negative conclusions appear to be context dependent, and a unified consensus has yet to be reached. The burgeoning body of research on the relationship between the gut microbiota and tumours in recent years has led to a growing understanding. Most studies have indicated that specific components of the gut microbiota, such as unique bacterial communities or specific secretory factors, play diverse roles in regulating immune cells within the TME, thereby influencing the prognosis and outcomes of cancer treatments. A detailed understanding of these factors could provide novel insights into the TME and cancer therapy. In this study, we aimed to synthesise information on the interactions between the gut microbiota and immune cells within the TME, providing an in-depth exploration of the potential guiding implications for future cancer therapies.