肠道菌群对免疫细胞相互作用和癌症治疗的影响
Influence of the gut microbiota on immune cell interactions and cancer treatment
影响因子:7.50000
分区:医学2区 Top / 医学：研究与实验2区
发表日期:2024 Oct 15
作者:
Chunxiao Liu, Lingfeng Fu, Yuxin Wang, Weijun Yang
摘要
肿瘤微环境代表了肿瘤学研究中的新型领域。在过去的十年中，积累的证据突显了肿瘤微环境（TME）的重要性，包括肿瘤细胞，基质细胞，免疫细胞和各种分泌因素，这些因素集体影响肿瘤生长，侵袭和对治疗剂的反应。现在，TME中的免疫细胞被广泛承认，可以在肿瘤发育和治疗中起关键作用。尽管某些观点认为TME中的免疫细胞促进了肿瘤的进展并赋予对治疗干预措施的抗性，但也存在对比的结论。肯定和负面的结论似乎取决于上下文，统一的共识尚未得出。近年来，关于肠道微生物群和肿瘤之间关系的研究迅速发展，导致人们越来越了解。大多数研究表明，肠道菌群的特定成分，例如独特的细菌群落或特定的分泌因素，在调节TME内的免疫细胞中起着不同的作用，从而影响了癌症治疗的预后和结果。对这些因素的详细理解可以为TME和癌症治疗提供新的见解。在这项研究中，我们旨在综合TME中肠道菌群与免疫细胞之间相互作用的信息，从而深入探索对未来癌症疗法的潜在指导意义。
Abstract
The tumour microenvironment represents a novel frontier in oncological research. Over the past decade, accumulating evidence has underscored the importance of the tumour microenvironment (TME), including tumour cells, stromal cells, immune cells, and various secreted factors, which collectively influence tumour growth, invasion, and responses to therapeutic agents. Immune cells within the TME are now widely acknowledged to play pivotal roles in tumour development and treatment. While some perspectives have posited that immune cells within the TME facilitate tumour progression and confer resistance to therapeutic interventions, contrasting conclusions also exist. Affirmative and negative conclusions appear to be context dependent, and a unified consensus has yet to be reached. The burgeoning body of research on the relationship between the gut microbiota and tumours in recent years has led to a growing understanding. Most studies have indicated that specific components of the gut microbiota, such as unique bacterial communities or specific secretory factors, play diverse roles in regulating immune cells within the TME, thereby influencing the prognosis and outcomes of cancer treatments. A detailed understanding of these factors could provide novel insights into the TME and cancer therapy. In this study, we aimed to synthesise information on the interactions between the gut microbiota and immune cells within the TME, providing an in-depth exploration of the potential guiding implications for future cancer therapies.