生物传感和成像中量子点的多功能方法
Versatile Approaches of Quantum Dots in Biosensing and Imaging
影响因子:8.20000
分区:医学2区 / 医学：研究与实验3区 纳米科技3区
发表日期:2024
作者:
Daphika S Dkhar, Rohini Kumari, Vinay Patel, Ananya Srivastava, Rajendra Prasad, Rohit Srivastava, Pranjal Chandra
摘要
尽管诊断，检测和治疗策略取得了长足的进步，但癌症仍被认为是巨大的全球健康威胁。在这些领域取得了显着的进步，但是几十年来，癌症患者的存活率持续了次优水平。认识到需要应对癌症生存率持续挑战的必要性，正在做出研究工作，以突破诊断技术，生物成像和药物输送技术的创新界限。在过去的几年中，基于Nano（Bio）的基于技术的方法已用于生物传感和成像应用，以检测各种矩阵中的生化物质。在各种纳米工程的颗粒中，量子点（QD）已被认为是这些应用的多功能剂。 QD（通常称为人造原子）的特征是具有显着的光学和电气特征，这些特征对于细胞传感，局部生物成像和疗法至关重要。在这篇综述中，我们讨论了各种QD作为敏感和选择性剂，用于精确感测和成像癌细胞。电化学和光学方法均已用于描述细胞传感检测方法。此外，还强调了恶性肿瘤细胞的生物成像和具有QD治疗反应的药物递送。这篇评论还列出了经常用于此类应用程序的几种QD，例如碳，石墨烯，锌和其他类型的基于混合的QD。最后，为了洞悉前瞻性研究，还强调了QD的优势和潜力。在本文中，我们还强调了局限性并解决了临床应用中与QD相关的困难，以便提供潜在解决方案的见解。
Abstract
Cancer is considered a formidable global health threat, despite substantial strides in diagnosis, detection, and therapeutic strategies. Remarkable progress has been achieved in these realms, yet the survival rates for cancer patients have persisted at suboptimal levels over decades. Acknowledging the need to address the ongoing challenges in cancer survival rates, research efforts are being made to push the boundaries of innovation in diagnostic techniques, bioimaging, and drug delivery technologies. Over the past few years, nano(bio)technology-based approaches have been applied for biosensing and imaging applications to detect biochemical substances in various matrices. Among various nanoengineered particulates, quantum dots (QDs) have been recognized as versatile agents for these applications. QDs, often called artificial atoms, are characterized by the remarkable optical and electrical features which are essential for cytosensing, localized bioimaging and therapeutics. Here in this review, we have discussed various QDs as sensitive and selective agents for precise sensing and imaging of cancer cells. Both electrochemical and optical approaches have been used to describe the cytosensing detection methods. Furthermore, the bioimaging of malignant tumor cells and the drug delivery with therapeutic responses of QDs have also been highlighted. This review also lists the several kinds of QDs that are frequently used for such kinds of applications, such as carbon, graphene, zinc, and other types of hybrid-based QDs. Finally, to shed insight on prospective research, the advantages and potential of QDs are also highlighted. In this article, we also emphasize the limitations and address the difficulties associated with QDs in clinical applications in order to provide insights for potential solutions.