量子点在生物传感与成像中的多功能应用
Versatile Approaches of Quantum Dots in Biosensing and Imaging
DOI 原文链接
用sci-hub下载
如无法下载，请从 Sci-Hub 选择可用站点尝试。
影响因子:8.2
分区:医学2区 / 医学：研究与实验3区 纳米科技3区
发表日期:2024
作者:
Daphika S Dkhar, Rohini Kumari, Vinay Patel, Ananya Srivastava, Rajendra Prasad, Rohit Srivastava, Pranjal Chandra
DOI:
10.1002/wnan.1998
摘要
癌症尽管在诊断、检测和治疗策略方面取得了巨大进展，但仍被视为全球健康的严重威胁。近年来，在这些领域已取得显著成就，但癌症患者的生存率仍长期处于较低水平。为应对持续存在的癌症生存挑战，科研力量不断推动诊断技术、生物成像和药物输送技术的创新突破。近年来，基于纳米（生物）技术的方法被应用于生物传感和成像，用于检测各种基质中的生化物质。在众多纳米工程颗粒中，量子点（QDs）被认为是多功能的优势载体。QDs常被称为人工原子，具有卓越的光学和电学特性，这些特性对于细胞传感、局部生物成像和治疗具有重要意义。在本综述中，我们讨论了多种QDs作为敏感且高选择性的检测剂，用于精确检测和成像癌细胞。既包括电化学方法，也包括光学方法，用于描述细胞传感的检测技术。此外，还强调了QDs在恶性肿瘤细胞生物成像以及药物递送与治疗反应中的应用。综述中列举了常用的几类QDs，如碳、石墨烯、锌及其他类型的杂化QDs。最后，展望未来研究，突出QDs的优势与潜力，同时也分析了其在临床应用中的局限性和面临的挑战，旨在提供潜在的解决方案。
Abstract
Cancer is considered a formidable global health threat, despite substantial strides in diagnosis, detection, and therapeutic strategies. Remarkable progress has been achieved in these realms, yet the survival rates for cancer patients have persisted at suboptimal levels over decades. Acknowledging the need to address the ongoing challenges in cancer survival rates, research efforts are being made to push the boundaries of innovation in diagnostic techniques, bioimaging, and drug delivery technologies. Over the past few years, nano(bio)technology-based approaches have been applied for biosensing and imaging applications to detect biochemical substances in various matrices. Among various nanoengineered particulates, quantum dots (QDs) have been recognized as versatile agents for these applications. QDs, often called artificial atoms, are characterized by the remarkable optical and electrical features which are essential for cytosensing, localized bioimaging and therapeutics. Here in this review, we have discussed various QDs as sensitive and selective agents for precise sensing and imaging of cancer cells. Both electrochemical and optical approaches have been used to describe the cytosensing detection methods. Furthermore, the bioimaging of malignant tumor cells and the drug delivery with therapeutic responses of QDs have also been highlighted. This review also lists the several kinds of QDs that are frequently used for such kinds of applications, such as carbon, graphene, zinc, and other types of hybrid-based QDs. Finally, to shed insight on prospective research, the advantages and potential of QDs are also highlighted. In this article, we also emphasize the limitations and address the difficulties associated with QDs in clinical applications in order to provide insights for potential solutions.