多年来，前列腺癌（PCa）研究引起了人们的极大兴趣，而微量金属由于与前列腺癌的发生和进展相关而引起了广泛关注。 PCa 的病因很复杂，与遗传、环境和生活方式因素有关。近年来，锌（Zn）、汞（Hg）、硒（Se）、铅（Pb）、镉（Cd）、锰（Mn）、砷（As）和镍（Ni）等微量金属引起了广泛关注。多年来，人们怀疑它们通过对前列腺癌组学（基因组学、表观遗传学、蛋白质组学和转录组学）的影响与癌症风险和进展的调节有直接联系。这导致它们成为这方面广泛研究的主题。在这篇综述中，我们探讨了微量金属的影响，并通过整合最新文献的发现，对微量金属如何在分子水平上影响前列腺癌生物学的现有知识进行了全面分析，以帮助为未来研究提出可能的方向。

Over the years, prostate cancer (PCa) research has been of great interest, and trace metals have attracted a lot of attention due to their association with prostate cancer development and progression. PCa has a complex etiology, with genetic, environmental, and lifestyle factors being implicated. Trace metals such as zinc (Zn), mercury (Hg), selenium (Se), lead (Pb), cadmium (Cd), manganese (Mn), arsenic (As), and nickel (Ni) have garnered much attention in recent years, suspected of having direct links to the modulation of cancer risk and progression through their impacts on prostate cancer omics (genomics, epigenetics, proteomics, and transcriptomics). This has led to them being the subject of extensive research in this regard. In this review, we explored the influence of trace metals and offered a comprehensive analysis of the current knowledge on how trace metals affect the biology of prostate cancer at a molecular level by integrating findings from the recent literature to help suggest possible directions for future research.