微量金属在前列腺癌发生与发展的作用
The Role of Trace Metals in the Development and Progression of Prostate Cancer
DOI 原文链接
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影响因子:4.9
分区:生物学3区 / 生化与分子生物学3区 化学：综合3区
发表日期:2024 Oct 05
作者:
Unathi Albertinah Tshoni, Thokozani P Mbonane, Phoka C Rathebe
DOI:
10.3390/ijms251910725
摘要
多年来，前列腺癌（PCa）研究受到极大关注，微量金属因其与前列腺癌的发生和发展相关而引起广泛注意。PCa具有复杂的病因，涉及遗传、环境和生活方式因素。近年来，锌（Zn）、汞（Hg）、硒（Se）、铅（Pb）、镉（Cd）、锰（Mn）、砷（As）和镍（Ni）等微量金属受到了特别关注，被怀疑通过影响前列腺癌的组学（基因组学、表观遗传学、蛋白质组学和转录组学）直接调节癌症风险和进展。本综述探讨了微量金属的影响，并结合最新文献，全面分析了它们在分子水平上如何影响前列腺癌的生物学，为未来的研究提供可能的方向。
Abstract
Over the years, prostate cancer (PCa) research has been of great interest, and trace metals have attracted a lot of attention due to their association with prostate cancer development and progression. PCa has a complex etiology, with genetic, environmental, and lifestyle factors being implicated. Trace metals such as zinc (Zn), mercury (Hg), selenium (Se), lead (Pb), cadmium (Cd), manganese (Mn), arsenic (As), and nickel (Ni) have garnered much attention in recent years, suspected of having direct links to the modulation of cancer risk and progression through their impacts on prostate cancer omics (genomics, epigenetics, proteomics, and transcriptomics). This has led to them being the subject of extensive research in this regard. In this review, we explored the influence of trace metals and offered a comprehensive analysis of the current knowledge on how trace metals affect the biology of prostate cancer at a molecular level by integrating findings from the recent literature to help suggest possible directions for future research.