评估预后因素，包括微生物组在内的临床特征以及未知主要部位癌症患者的治疗结果

未知的原发性部位癌（CUP）是一组异质的癌症，发现转移，并且未通过可用的诊断方法检测到原发性肿瘤。杯子是一种尚未得到充分研究的疾病，其生物学尚不清楚。杯子的临床特征是可变的，但是患者的预后通常不利，并且自由基治疗的可能性受到限制。微生物组是驻留在人体中的微生物的基因和基因产物。近年来，由于使用了下一代测序，因此可以评估微生物组对人体功能的影响。由于该地区的微生物组丰富，头颈癌受到其影响，营养不良可能是癌症发展的危险因素。 Objective of this work: the aim of this study was to evaluate prognostic factors, clinical features including the microbiome, and treatment outcomes in patients with cancer of unknown primary site.in the study group, increased numbers of bacteria of the phyla Bacteroides, Fusobacteria, Bacillota, Actinomycetota, Actinobacteria, and Candidatus were detected, while Firmicutes and Proteobacteria were detected in smaller数字。杯赛发生的独立预测指标如下：白细胞计数最多为6.49×103/mm，微生物组低于11.6％的蛋白质细菌的细菌，低于22.1％的企业，而静脉内则至少11.0％。卟啉单胞菌数量增加和梭菌细菌与放射疗法并发症的风险和存活率缩短有关。由于对这个问题缺乏共识，临床诊断和杯赛患者的临床诊断和治疗是复杂而困难的。杯赛患者的治疗和预后不令人满意。微生物组对癌症发育，过程和治疗的影响的临床价值变得越来越重要。微生物组可能成为对抗癌治疗及其并发症风险的反应标志。微生物组的免疫调节为改善肿瘤治疗的有效性提供了进一步研究的机会。梭杆菌和卟啉单胞菌似乎是对癌症发展最重要的细菌，也通过增加放疗并发症的风险并缩短患者的存活率，从而恶化了患者的预后。链球菌和乳杆菌似乎是降低癌症风险，降低并发症的风险并改善患者预后的细菌。总蛋白质缺乏症和炎症标记升高也是癌症风险的重要预测指标。

cancer of unknown primary site (CUP) is a heterogeneous group of cancers in which metastases are found, and the primary tumor is not detected with available diagnostic methods. CUP is a disease that has not been fully researched, and its biology is unclear. The clinical characteristics of CUP are variable, but the prognosis of patients is usually unfavorable, and the possibilities of radical treatment are limited. The microbiome is the genes and gene products of microorganisms residing in a human body. In recent years, thanks to the use of next-generation sequencing, it is possible to assess the impact of the microbiome on human body functions. Head and neck cancers, due to the rich microbiome of this area, are influenced by it, and dysbiosis may be a risk factor for the development of cancer. Objective of this work: the aim of this study was to evaluate prognostic factors, clinical features including the microbiome, and treatment outcomes in patients with cancer of unknown primary site.in the study group, increased numbers of bacteria of the phyla Bacteroides, Fusobacteria, Bacillota, Actinomycetota, Actinobacteria, and Candidatus were detected, while Firmicutes and Proteobacteria were detected in smaller numbers. Independent predictors of CUP occurrence were the following: leukocyte count of at most 6.49 × 103/mm, bacteria from the Proteobacteria phylum in the microbiome below 11.6%, Firmicutes below 22.1%, and Actinobacteria at least 11.0%. Increased numbers of Porphyromonas and Fusobacterium bacteria were associated with the risk of radiotherapy complications and shortened survival rate.clinical diagnosis and treatment of patients with CUP is complicated and difficult due to the lack of consensus on this issue. Treatment and prognosis of patients with CUP is unsatisfactory. The clinical value of the influence of the microbiome on the development, course, and treatment of cancer is becoming increasingly important. The microbiome may become a marker of response to anticancer treatment and the risk of its complications. Immunity modulation with the microbiome provides opportunities for further research on improving the effectiveness of oncological treatment. Fusobacterium and Porphyromonas seem to be the bacteria most important for the development of cancer, also worsening the prognosis of patients by increasing the risk of complications of radiotherapy and shortening the survival rate of patients. Streptococcus and Lactobacillus seem to be bacteria that reduce the risk of cancer, reduce the risk of complications, and improve the prognosis of patients. Total protein deficiency and elevated inflammatory markers are also important predictors of cancer risk.