个性化放射治疗：应用及未来发展方向
Personalized Brachytherapy: Applications and Future Directions
DOI 原文链接
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影响因子:4.4
分区:医学3区 / 肿瘤学3区
发表日期:2024 Oct 09
作者:
Piyush Pathak, Justin J Thomas, Arjit Baghwala, Chengfeng Li, Bin S Teh, Edward B Butler, Andrew M Farach
DOI:
10.3390/cancers16193424
摘要
放射治疗提供了一种高度符合和适应性强的肿瘤放疗方法。本文综述了个性化放射治疗的理论基础、应用领域、技术进步及未来发展趋势。先进影像技术、3D打印适配器及人工智能的集成，正迅速提升放射治疗的精确性和效率；基因检测和分子生物标志物则在患者筛选和剂量调整中发挥着日益重要的作用。结合免疫治疗的研究日益增多，显示出协同增强的潜力；同时，强度调制和屏蔽适配器等新技术为优化剂量分布提供了新的可能性。尽管取得了诸多进展，行业仍面临培训需求增加和拓展治疗范围的挑战。随着个性化医学的发展，放射治疗凭借其精准、个体化的优势，将成为未来肿瘤治疗的重要组成部分。
Abstract
Brachytherapy offers a highly conformal and adaptive approach to radiation therapy for various oncologic conditions. This review explores the rationale, applications, technological advances, and future directions of personalized brachytherapy. Integration of advanced imaging techniques, 3D-printed applicators, and artificial intelligence are rapidly enhancing brachytherapy delivery and efficiency, while genomic tests and molecular biomarkers are refining patient and dose selection. Emerging research on combining brachytherapy with immunotherapy offers unique synergistic potential, and technologies such as intensity-modulated and shielded brachytherapy applicators present novel opportunities to further optimize dose distributions. Despite these promising advances, the field faces challenges including a need to train more practitioners and develop new approaches to treating a broader range of malignancies. As personalized medicine evolves, brachytherapy's ability to deliver highly targeted, individualized treatments positions it as a critical component in future cancer care.