个性化的近距离放射治疗：应用和未来方向
Personalized Brachytherapy: Applications and Future Directions
影响因子:4.40000
分区:医学3区 / 肿瘤学3区
发表日期:2024 Oct 09
作者:
Piyush Pathak, Justin J Thomas, Arjit Baghwala, Chengfeng Li, Bin S Teh, Edward B Butler, Andrew M Farach
摘要
近距离放射治疗为各种肿瘤疾病提供了高度保形和适应性的放射治疗方法。这篇评论探讨了个性化近距离疗法的基本原理，应用，技术进步以及未来的方向。高级成像技术，3D打印涂抹器和人工智能的整合正在迅速增强近距离放射疗法和效率，而基因组测试和分子生物标志物正在完善患者和剂量选择。关于将近距离放射治疗与免疫疗法相结合的新兴研究具有独特的协同潜力，以及诸如强度调节和屏蔽的近距离近距离疗法施用者等技术提供了新的机会，以进一步优化剂量分布。尽管这些有希望的进步，但该领域仍面临挑战，包括需要培训更多的从业者并开发新的方法来治疗更广泛的恶性肿瘤。随着个性化医学的发展，近距离放射治疗能够提供高度针对性的个性化疗法将其定位为未来癌症护理的关键组成部分。
Abstract
Brachytherapy offers a highly conformal and adaptive approach to radiation therapy for various oncologic conditions. This review explores the rationale, applications, technological advances, and future directions of personalized brachytherapy. Integration of advanced imaging techniques, 3D-printed applicators, and artificial intelligence are rapidly enhancing brachytherapy delivery and efficiency, while genomic tests and molecular biomarkers are refining patient and dose selection. Emerging research on combining brachytherapy with immunotherapy offers unique synergistic potential, and technologies such as intensity-modulated and shielded brachytherapy applicators present novel opportunities to further optimize dose distributions. Despite these promising advances, the field faces challenges including a need to train more practitioners and develop new approaches to treating a broader range of malignancies. As personalized medicine evolves, brachytherapy's ability to deliver highly targeted, individualized treatments positions it as a critical component in future cancer care.