胃肠胰神经内分泌肿瘤（GEP NEN）的发病率正在快速增加，并成为临床护理中越来越重要的考虑因素。来自多个国家的流行病学数据表明，胃肠胰神经内分泌肿瘤（GEP NEN）的发病率表现出区域性、部位特异性和性别差异。虽然一些 GEP NEN，特别是胰腺 NEN 的遗传学和发病机制已得到研究，但仍有许多机制需要进一步研究。 GEP NEN 的治疗方法多种多样，但手术仍然是大多数病例的主要选择。肽受体放射性核素疗法 (PRRT) 是一种有效的治疗方法，多项临床试验正在探索免疫疗法和靶向疗法以及联合疗法的潜力。版权所有 © 2024 Tan、Zhang 和 Chen。

The incidence of gastroenteropancreatic neuroendocrine neoplasms (GEP NEN) is increasing at a rapid pace and is becoming an increasingly important consideration in clinical care. Epidemiological data from multiple countries indicate that the incidence of gastroenteropancreatic neuroendocrine neoplasms (GEP NEN) exhibits regional, site-specific, and gender-based variations. While the genetics and pathogenesis of some GEP NEN, particularly pancreatic NENs, have been investigated, there are still many mechanisms that require further investigation. The management of GEP NEN is diverse, but surgery remains the primary option for most cases. Peptide receptor radionuclide therapy (PRRT) is an effective treatment, and several clinical trials are exploring the potential of immunotherapy and targeted therapy, as well as combination therapy.Copyright © 2024 Tan, Zhang and Chen.