为了调查美国成年人代表性队列中卡波西肉瘤相关疱疹病毒 (KSHV)/人类疱疹病毒 8 (HHV8) 感染与全因死亡率和心血管死亡率之间的关联，数据来自国家健康和营养检查调查 III (NHANES III) ; 1988-1994）进行了分析，包括 13,993 名年龄在 18-90 岁的参与者，他们接受了 KSHV 血清学评估。截至 2019 年 12 月，死亡率结果是使用国家死亡指数确定的。采用 Cox 比例风险模型来检查 KSHV 血清阳性与死亡率之间的关联，并调整年龄、性别、种族、体重指数和血清 TG 等潜在混杂因素。在 26.5 年的中位随访期内，记录了 5503 例死亡。 KSHV 血清阳性与全因死亡率（风险比 [HR]：1.32，95% 置信区间 [CI]：1.03-1.69）和心血管死亡率（HR：1.58，95% CI：1.00-2.50）风险增加相关调整年龄、性别、种族和体重指数后。值得注意的是，在调整所有混杂因素后，KSHV 感染与全因死亡率之间的关联在女性中仍然存在（HR：1.32，95% CI：1.02-1.72），而与心血管死亡率的关联仅在男性中具有统计学显着性（HR：1.90） , 95% CI: 1.02, 3.53）。KSHV 感染可能是美国成年人全因死亡和心血管死亡的独立危险因素。这些发现强调需要进一步研究来验证独立人群中的这些关联，并阐明观察到的与 KSHV 感染相关的死亡率增加的生物学机制。© 2024 Wiley periodicals LLC。

To investigate the association between Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8 (HHV8) infection and both all-cause and cardiovascular mortality in a representative cohort of US adults, data from the National Health and Nutrition Examination Survey III (NHANES III; 1988‒1994) were analyzed, including 13,993 participants aged 18‒90 years who underwent KSHV serology evaluations. Mortality outcomes were ascertained through December 2019 using the National Death Index. Cox proportional hazards models were employed to examine the association between KSHV seropositivity and mortality, adjusting for potential confounders such as age, sex, ethnicity, body mass index, and serum TG. Over a median follow-up period of 26.5 years, 5503 deaths were recorded. KSHV seropositivity was associated with an increased hazard of all-cause mortality (Hazard Ratio [HR]: 1.32, 95% Confidence Interval [CI]: 1.03‒1.69) and cardiovascular mortality (HR: 1.58, 95% CI: 1.00‒2.50) after adjusting for age, sex, ethnicity, and body mass index. Notably, the association between KSHV infection and all-cause mortality persisted among women (HR: 1.32, 95% CI: 1.02‒1.72) after adjusting for all confounders, whereas the association with cardiovascular mortality was only statistically significant for men (HR: 1.90, 95% CI: 1.02, 3.53).KSHV infection may represent an independent risk factor for all-cause and cardiovascular mortality among US adults. These findings highlight the need for further research to validate these associations in independent populations and to elucidate the biological mechanisms underlying the observed increased mortality associated with KSHV infection.© 2024 Wiley Periodicals LLC.