卡波西（Kaposi）与肉瘤相关的疱疹病毒感染及其与一般成年人的全因和心血管死亡率的关联：一项前瞻性队列研究
Kaposi's sarcoma-associated herpesvirus infection and its association with all-cause and cardiovascular mortality in the general adults: A prospective cohort study
影响因子:4.60000
分区:医学3区 / 病毒学3区
发表日期:2024 Oct
作者:
Xiaoping Huang, Xueliang Huang, Yushao Li, Lixia Li, Jiaman Liao, Hao Huang, Ying Zhao, Yiqiang Zhan
摘要
调查Kaposi与肉瘤相关的疱疹病毒（KSHV）/人类疱疹病毒8（HHV8）感染与美国成年人代表的全因和心血管死亡率之间的联系经过KSHV血清学评估的年代。使用国家死亡指数在2019年12月之前确定死亡率结果。使用COX比例危害模型来检查KSHV血清阳性和死亡率之间的关联，并调整了年龄，性别，种族，体重指数和血清TG等潜在混杂因素。在中位随访期为26。5年的时间里，记录了5503例死亡。 KSHV血清阳性与全因死亡率的危害增加有关（危险比[HR]：1.32，95％置信区间[CI]：1.03 - 1.69）和心血管死亡率（HR：1.58，95％CI：1.00：00：00-2.50）在适应年龄，性别，性爱，族裔和族裔和体外质量和体内和体内及其后。值得注意的是，在调整了所有混杂因素之后，妇女之间KSHV感染与全因死亡率之间的关联持续存在（HR：1.32，95％CI：1.02至1.72），而与心血管死亡率相关，而男性仅对男性具有统计学意义（HR：1.90，95％CI：1.95％CI：1.02，3.53，3.53）。。。。。。。。。。。。。。。。。美国成年人的心血管死亡率。这些发现凸显了需要进一步研究以验证独立人群中这些关联的必要性，并阐明观察到的与KSHV感染相关的死亡率增加的生物学机制。
Abstract
To investigate the association between Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8 (HHV8) infection and both all-cause and cardiovascular mortality in a representative cohort of US adults, data from the National Health and Nutrition Examination Survey III (NHANES III; 1988‒1994) were analyzed, including 13,993 participants aged 18‒90 years who underwent KSHV serology evaluations. Mortality outcomes were ascertained through December 2019 using the National Death Index. Cox proportional hazards models were employed to examine the association between KSHV seropositivity and mortality, adjusting for potential confounders such as age, sex, ethnicity, body mass index, and serum TG. Over a median follow-up period of 26.5 years, 5503 deaths were recorded. KSHV seropositivity was associated with an increased hazard of all-cause mortality (Hazard Ratio [HR]: 1.32, 95% Confidence Interval [CI]: 1.03‒1.69) and cardiovascular mortality (HR: 1.58, 95% CI: 1.00‒2.50) after adjusting for age, sex, ethnicity, and body mass index. Notably, the association between KSHV infection and all-cause mortality persisted among women (HR: 1.32, 95% CI: 1.02‒1.72) after adjusting for all confounders, whereas the association with cardiovascular mortality was only statistically significant for men (HR: 1.90, 95% CI: 1.02, 3.53).KSHV infection may represent an independent risk factor for all-cause and cardiovascular mortality among US adults. These findings highlight the need for further research to validate these associations in independent populations and to elucidate the biological mechanisms underlying the observed increased mortality associated with KSHV infection.