在不断发展的癌症治疗领域，治疗性肽发挥着越来越重要的作用。尽管目前可用于临床癌症治疗的肽药物数量有限，但广泛的临床前研究正在进行中，为未来呈现了充满希望的轨迹。在分子生物学和肽化学进步的推动下，天然抗癌肽 (ACP) 和合成 ACP 的共同努力正在推动这一领域取得显着进展。我们探索这些肽抗癌作用的复杂机制。创新策略的探索，包括癌症免疫治疗和先进的药物输送系统，可能有助于肽药物在临床癌症治疗中的使用增加。此外，我们深入研究了与这一预期转变相关的潜在影响和挑战，强调需要继续研究和开发，以释放肽药物在癌症治疗中的全部治疗潜力。版权所有 © 2024。由 Elsevier B.V. 出版。

In the evolving landscape of cancer treatment, therapeutic peptides are assuming to play an increasingly vital role. Although the number of peptide drugs available for clinical cancer treatment is currently limited, extensive preclinical research is underway, presenting a promising trajectory for the future. The collaborative efforts of natural anti-cancer peptides (ACPs) and synthetic ACPs, propelled by advancements in molecular biology and peptide chemistry, are steering remarkable progress in this domain. We explores the intricate mechanisms underlying the anti-cancer effects of these peptides. The exploration of innovative strategies, including cancer immunotherapy and advanced drug delivery systems, is likely to contribute to the increasing presenceuse of peptide drugs in clinical cancer care. Furthermore, we delve into the potential implications and challenges associated with this anticipated shift, empHasizing the need for continued research and development to unlock the full therapeutic potential of peptide drugs in cancer treatment.Copyright © 2024. Published by Elsevier B.V.