gp130 不仅作为白细胞介素 (IL)-6 的共享信号转导亚基，而且还作为其他八种人类细胞因子受体复合物的共享信号转导亚基。通过 gp130 介导的 IL-6 信号传导途径涵盖经典、反式或簇信号传导，并受到影响 IL-6、其受体和 gp130 的多种调节剂的复杂调节。目前，仅已知有限数量的 gp130 小分子拮抗剂和激动剂。本综述旨在全面检查这些调节剂的当前知识，并深入了解它们的药理学特性，特别是在癌症和其他疾病的背景下。值得注意的是，详细讨论了著名的 gp130 调节剂 SC144、巴多昔芬和雷洛昔芬，特别关注 SC144 铁螯合特性的发现。这为了解其药理作用和在铁稳态重要的情况下的治疗潜力增加了一个新的维度。我们对 gp130 和铁稳态相关基因的生物信息分析揭示了深刻的相关性，暗示了铁在 gp130 信号通路中的作用。总的来说，这篇综述有助于加深对 gp130 调节及其在各种疾病背景下的潜在治疗应用的理解。意义声明：这一观点对 gp130 信号研究的进展提供了及时、全面的分析，强调了当前可用调节剂的治疗意义。生物信息分析表明 gp130 和调节铁稳态的基因之间潜在的相互作用，提出了新的治疗途径。通过将原始研究结果与对 gp130 治疗潜力的更广泛讨论相结合，这一观点对该领域做出了重大贡献。版权所有 © 2024，作者。

gp130 functions as a shared signal-transducing subunit not only for interleukin (IL)-6 but also for eight other human cytokine receptor complexes. The IL-6 signaling pathway mediated through gp130 encompasses classical, trans, or cluster signaling, intricately regulated by a diverse array of modulators affecting IL-6, its receptor, and gp130. Currently, only a limited number of small molecule antagonists and agonists for gp130 are known. This review aims to comprehensively examine the current knowledge of these modulators and provide insights into their pharmacological properties, particularly in the context of cancer and other diseases. Notably, the prominent gp130 modulators SC144, bazedoxifene, and raloxifene are discussed in detail, with a specific focus on the discovery of SC144's iron-chelating properties. This adds a new dimension to the understanding of its pharmacological effects and therapeutic potential in conditions where iron homeostasis is significant. Our bioinformatic analysis of gp130 and genes related to iron homeostasis reveals insightful correlations, implicating the role of iron in the gp130 signaling pathway. Overall, this review contributes to the evolving understanding of gp130 modulation and its potential therapeutic applications in various disease contexts. SIGNIFICANCE STATEMENT: This perspective provides a timely and comprehensive analysis of advancements in gp130 signaling research, emphasizing the therapeutic implications of the currently available modulators. Bioinformatic analysis demonstrates potential interplay between gp130 and genes that regulate iron homeostasis, suggesting new therapeutic avenues. By combining original research findings with a broader discussion of gp130's therapeutic potential, this perspective significantly contributes to the field.Copyright © 2024 by The Author(s).