肺部过度充气是慢性阻塞性肺病 (COPD) 呼吸困难的一个关键因素，可以通过胸部计算机断层扫描 (CT) 进行量化。建立肺叶容积和肺总容积 (TLV) 的参考方程有助于评估肺叶过度充气，特别是对于有针对性的肺减容治疗。生命线成像研究 (ImaLife) 包括 11,729 名 45 岁及以上的参与者，分析了吸气低剂量胸腔CT 扫描。使用基于人工智能的自动分割算法（LungSeg）测量肺和肺叶体积。对于主要分析，如果参与者自我报告患有慢性阻塞性肺病/哮喘、CT 肺部疾病、肺功能测试中气流阻塞、目前吸烟、年龄超过 80 岁或身高超出 99% 置信区间，则被排除在外。 TLV 和肺叶体积的参考方程是使用线性回归确定的，考虑了年龄和身高，按性别分层。对于亚分析，将当前吸烟或经历气流阻塞的参与者与主要分析组进行比较。该研究包括 7306 名肺部健康的参与者，其中 97.5% 为白人，43.6% 为男性，平均年龄为 60.3±9.5 岁。肺和肺叶的体积通常随着年龄和身高而增加。根据身高调整后，男性的体积始终高于女性。 R2 值范围为 7.8% 至 19.9%。吸烟者和气道阻塞患者的肺容量大于肺部健康人群，其中上肺叶的增幅最大。CT 得出的 TLV 和肺叶容量的既定参考方程为 45 至 80 岁的个体提供了标准化解释北欧血统。问题 肺叶肺容量可以通过吸气 CT 扫描得出，但缺乏健康肺参考值。研究结果 肺和肺叶的体积通常随着年龄和身高的增加而增加。肺/肺叶体积的参考方程是从相当大的肺健康人群中得出的。临床相关性 这项研究为肺部健康人群中吸气 CT 得出的肺和肺叶体积提供了参考方程，可能有助于评估肺减容疗法的候选者、肺癌患者的肺叶切除以及限制性肺部疾病的情况。 © 2024。作者。

Lung hyperinflation, a key contributor to dyspnea in chronic obstructive pulmonary disease (COPD), can be quantified via chest computed tomography (CT). Establishing reference equations for lobar volumes and total lung volume (TLV) can aid in evaluating lobar hyperinflation, especially for targeted lung volume reduction therapies.The Imaging in Lifelines study (ImaLife) comprises 11,729 participants aged 45 and above with analyzed inspiratory low-dose thoracic CT scans. Lung and lobar volumes were measured using an automatic AI-based segmentation algorithm (LungSeg). For the main analysis, participants were excluded if they had self-reported COPD/asthma, lung disease on CT, airflow obstruction on lung function testing, were currently smoking, aged over 80 years, or had height outside the 99% confidence interval. Reference equations for TLV and lobar volumes were determined using linear regression considering age and height, stratified by sex. For the subanalysis, participants who were currently smoking or experiencing airflow obstruction were compared to the group of the main analysis.The study included 7306 lung-healthy participants, 97.5% Caucasian, 43.6% men, with mean age of 60.3 ± 9.5 years. Lung and lobar volumes generally increased with age and height. Men consistently had higher volumes than women when adjusted for height. R2 values ranged from 7.8 to 19.9%. In smokers and those with airway obstruction, volumes were larger than in lung-healthy groups, with the largest increases measured in the upper lobes.The established reference equations for CT-derived TLV and lobar volumes provide a standardized interpretation for individuals aged 45 to 80 of Northern European descent.Question Lobar lung volumes can be derived from inspiratory CT scans, but healthy-lung reference values are lacking. Findings Lung and lobar volumes generally increased with age and height. Reference equations for lung/lobar volumes were derived from a sizeable lung-healthy population. Clinical relevance This study provides reference equations for inspiratory CT-derived lung and lobar volumes in a lung-healthy population, potentially useful for assessing candidates for lung volume reduction therapies, for lobe removal in lung cancer patients, and in case of restrictive pulmonary diseases.© 2024. The Author(s).